Overview
- Product nameAnti-CD105 antibody, predilutedSee all CD105 primary antibodies ...
- DescriptionRabbit polyclonal to CD105, prediluted
- SpecificityWe have data to indicate that this antibody may not cross react with Rat. However, this has not been conclusively tested and expression levels may vary in certain cell lines/tissues.
- Tested applicationsIHC-P, IHC-Glut more details
- Species reactivityReacts with: Human
- Immunogen
Recombinant fragment, corresponding to amino acids 26-176 of Human CD105.
- Positive controlHuman tonsil for Immunohistochemistry.
Properties
- FormPrediluted
- Storage instructionsStore at +4°C.
- Storage bufferPreservative: 0.1% Sodium Azide
Constituents: PBS, BSA -
Concentration information loading... - PurityImmunogen affinity purified
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab27422 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| IHC-P | IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Ready to use. 30 min at room temperature. |
| IHC-Glut | IHC-Glut: Use at an assay dependent concentration. PubMed: 22886085 |
Target
- FunctionMajor glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
- Tissue specificityEndoglin is restricted to endothelial cells in all tissues except bone marrow.
- Involvement in diseaseDefects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300, 108010]; also known as Osler-Rendu-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
- Cellular localizationMembrane.
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Database links
- Entrez Gene: 2022 Human
- Omim: 131195 Human
- SwissProt: P17813 Human
- Unigene: 76753 Human
Target information above from: UniProt accession
P17813
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- CD 105 antibodyCD105 antibodyCD105 antigen antibody
- EGLN_HUMAN antibodyEND antibodyEndoglin antibodyENG antibodyFLJ41744 antibodyHHT1 antibodyORW antibodyORW1 antibodyOsler Rendu Weber syndrome 1 antibodyRP11 228B15.2 antibodySN6 antibody
see all
Anti-CD105 antibody, prediluted images
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Immunohistochemistry (Formalin-fixed paraffin-embedded sections) - CD105 antibody, prediluted (ab27422)Ab27422, prediluted, staining CD105 in formalin fixed, paraffin embedded human tonsil tissue by Immunohistochemistry.
References for Anti-CD105 antibody, prediluted (ab27422)
This product has been referenced in:
- Virgintino D et al. Plasma membrane-derived microvesicles released from tip endothelial cells during vascular sprouting. Angiogenesis 15:761-9 (2012). IHC-Glut ; Human . Read more (PubMed: 22886085) »
- Tront JS et al. Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress. Cancer Res 70:9671-81 (2010). IHC-P ; Mouse . Read more (PubMed: 21098706) »
