Anti-CD11+CD18 antibody [24] (ab13219)
Key features and details
- Mouse monoclonal [24] to CD11+CD18
- Suitable for: IP, RIA, ICC/IF, WB, Flow Cyt
- Reacts with: Mouse, Rat, Dog, Human
- Isotype: IgG1
Related conjugates and formulations
Overview
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Product name
Anti-CD11+CD18 antibody [24]
See all CD11+CD18 primary antibodies -
Description
Mouse monoclonal [24] to CD11+CD18 -
Host species
Mouse -
Specificity
This antibody specifically recognises the human CD11+CD18 activation epitope. -
Tested applications
Suitable for: IP, RIA, ICC/IF, WB, Flow Cytmore details -
Species reactivity
Reacts with: Mouse, Rat, Dog, Human -
Immunogen
Tissue, cells or virus corresponding to Human CD11+CD18. Fibronectin-purified human monocytes.
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Epitope
Recognises an epitope which is expressed by beta 2 (CD18) integrins in high affinity conformation. -
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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Purity
Protein A/G purified -
Clonality
Monoclonal -
Clone number
24 -
Myeloma
Sp2/0-Ag14 -
Isotype
IgG1 -
Research areas
Associated products
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Alternative Versions
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Compatible Secondaries
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Conjugation kits
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab13219 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IP |
Use at an assay dependent concentration.
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RIA |
Use at an assay dependent concentration.
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ICC/IF |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 129 kDa. PubMed: 22473604
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Flow Cyt | (5) |
Use at an assay dependent concentration.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Notes |
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IP
Use at an assay dependent concentration. |
RIA
Use at an assay dependent concentration. |
ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. Predicted molecular weight: 129 kDa. PubMed: 22473604 |
Flow Cyt
Use at an assay dependent concentration. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
Target
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Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. -
Tissue specificity
Leukocytes. -
Sequence similarities
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
Domain
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 3683 Human
- Entrez Gene: 3684 Human
- Entrez Gene: 3687 Human
- Entrez Gene: 3689 Human
- Entrez Gene: 16408 Mouse
- Entrez Gene: 16409 Mouse
- Entrez Gene: 16414 Mouse
- Entrez Gene: 25021 Rat
see all -
Alternative names
- Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide antibody
- CD11 antigen-like family member A antibody
- CD11a antibody
see all
Datasheets and documents
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SDS download
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Datasheet download
References (23)
ab13219 has been referenced in 23 publications.
- Nandagopal S et al. C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models. Cancer Immunol Res 10:245-258 (2022). PubMed: 34819308
- Rossatti P et al. Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation. BMC Biol 20:189 (2022). PubMed: 36002835
- Chen Y et al. The Mechanism of Alisol B23 Acetate Inhibiting Lung Cancer: Targeted Regulation of CD11b/CD18 to Influence Macrophage Polarization. Drug Des Devel Ther 16:3677-3689 (2022). PubMed: 36277599
- Cao JY et al. Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics 11:5248-5266 (2021). PubMed: 33859745
- Severic M et al. Genetically-engineered anti-PSMA exosome mimetics targeting advanced prostate cancer in vitro and in vivo. J Control Release 330:101-110 (2021). PubMed: 33333118