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Anti-CD11b antibody [44aacb] (FITC) (ab86893)

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Overview

  • Product nameAnti-CD11b antibody [44aacb] (FITC)See all CD11b primary antibodies ...
  • Description
    Mouse monoclonal [44aacb] to CD11b (FITC)
  • ConjugationFITC
  • Tested applicationsFlow Cyt more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    This information is considered to be commercially sensitive

  • Positive controlHuman lymphocytes.

Applications

Our Abpromise guarantee covers the use of ab86893 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt
  • Application notesFlow Cyt: Use 10µl (or 0.25µg) for 106 cells.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionIntegrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
    • Tissue specificityPredominantly expressed in monocytes and granulocytes.
    • Involvement in diseaseGenetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
    • Sequence similaritiesBelongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
      Contains 1 VWFA domain.
    • DomainThe integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
    • Cellular localizationMembrane.

      • Target information above from: UniProt accession P11215 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          Antigen CD11b p170 antibodyCD11 antigen like family member B antibodyCD11 antigen-like family member B antibody
          CD11b antibodyCD11b/CD18 antibodyCD49d antibodyCell surface glycoprotein MAC-1 subunit alpha antibodyComplement component 3 receptor 3 subunit antibodyComplement Component Receptor 3 Alpha antibodyComplement receptor type 3, alpha subunit antibodyCR 3 alpha chain antibodyCR-3 alpha chain antibodyCR3 antibodyCR3A antibodyF730045J24Rik antibodyIntegrin Alpha M antibodyIntegrin alpha M chain antibodyIntegrin alpha-M antibodyIntegrin beta 2 alpha subunit antibodyITAM_HUMAN antibodyITGAM antibodyLeukocyte Adhesion Receptor MO1 antibodyLy-40 antibodyMAC 1 antibodyMac-1a antibodyMAC1 antibodyMac1, alpha subunit antibodyMAC1A antibodyMacrophage antigen alpha polypeptide antibodyMGC117044 antibodyMo1, alpha subunit antibodyMO1A antibodyNeutrophil adherence receptor alpha M subunit antibodyNeutrophil Adherence Receptor antibodySLEB6 antibody
        see all

      Anti-CD11b antibody [44aacb] (FITC) images

      • Flow Cytometry - CD11b antibody [44aacb] (FITC) (ab86893)
        Flow Cytometry - CD11b antibody [44aacb] (FITC) (ab86893)
        Cell surface flow cytometric analysis of human CD11b in human lymphocytes using 10µl of ab86893. Shaded histogram represents cells without antibody; green represents isotype control; red represents anti-human CD11b antibody.

      References for Anti-CD11b antibody [44aacb] (FITC) (ab86893)

      ab86893 has not yet been referenced specifically in any publications.

      Publishing research using ab86893 ? Please let us know so that we can cite the reference in this datasheet

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