You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-CD147 antibody (ab11572)

CodeSizePriceAbpointsAvailability
    
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-CD147 antibody
See all CD147 products (31) ...

Description

Goat polyclonal to CD147

Tested applications

IHC-P, WB, ELISAmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Recombinant extracellular domain (Human), expressed in mouse myeloma NSO cells.

General notes

Do not store in frost-free freezer. Endotoxin level is < 15 ng/mg antibody as determined by the LAL (Limulus amebocyte lysate) method.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

Immunogen affinity purified

Clonality

Polyclonal

Isotype

IgG

Applications

Show applications key

Our Abpromise guarantee covers the use of ab11572 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     
  • WB

     
  • ELISA

     

Application notes

IHC-P: 1/25.
ELISA: Use at a concentration of 0.5 - 1 µg/ml. The detection limit for recombinant mouse EMMPRIN is approximately 0.2 ng/well.
WB: Use at a concentration of 0.1 - 0.2 µg/ml. The detection limit for mouse EMMPRIN is approximately 1 ng/lane under non-reducing and reducing conditions. Detects a band of approximately 58 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

Tissue specificity

Present only in vascular endothelium in non-neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Sequence similarities

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Post-translational
modifications

N-glycosylated.

Cellular localization

Cell membrane. Melanosome. Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Target information above from: UniProt accessionP35613 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • 5A11 antigen antibody
  • 5F7 antibody
  • 5F7 antibody
  • BASI_HUMAN antibody
  • Basigin (Ok blood group) antibody
  • Basigin antibody
  • Blood brain barrier HT7 antigen antibody
  • Blood-brain barrier HT7 antigen antibody
  • BSG antibody
  • CD 147 antibody
  • CD147 antibody
  • CD147 antigen antibody
  • Collagenase stimulatory factor antibody
  • Emmprin antibody
  • Emmprin antibody
  • Extracellular matrix metalloproteinase inducer antibody
  • Leukocyte activation antigen M6 antibody
  • M 6 antibody
  • M6 antibody
  • M6 antibody
  • M6 antigen antibody
  • M6 leukocyte activation antigen antibody
  • neurothelin antibody
  • OK antibody
  • OK blood group antibody
  • OK blood group antigen antibody
  • TCSF antibody
  • TCSF antibody
  • Tumor cell derived collagenase stimulatory factor antibody
  • Tumor cell-derived collagenase stimulatory factor antibody
see all

References for Anti-CD147 antibody (ab11572)

This product has been referenced in:

  • Hernández Iet al. Novel alternatively spliced ADAM8 isoforms contribute to the aggressive bone metastatic phenotype of lung cancer. Oncogene 29:3758-69 (2010).Read more (PubMed: 20453887) »
  • Kirwan RPet al. Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro. Mol Vis 11:798-810 (2005).Read more (PubMed: 16205625) »

See all 2 publications for this product

Publishing research using ab11572? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"