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Product Name
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CD147 antibody
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See all CD147 antibodies (21)...
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Product type
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Primary antibodies
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Description
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Goat polyclonal to CD147
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Immunogen
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Recombinant extracellular domain (Human), expressed in mouse myeloma NSO cells.
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Reacts with
(species key)
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Hu, Ms
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Tested applications
(see key)
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ELISA, IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/25.
ELISA: Use at a concentration of 0.5 - 1 µg/ml. The detection limit for recombinant mouse EMMPRIN is approximately 0.2 ng/well.
WB: Use at a concentration of 0.1 - 0.2 µg/ml. The detection limit for mouse EMMPRIN is approximately 1 ng/lane under non-reducing and reducing conditions. Detects a band of approximately 58 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Type I membrane protein
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Research areas
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Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of carbohydrates
Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Sensory System >> Visual system
Immunology >> Cell Type Markers >> CD >> Endothelial Cells
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Relevance
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CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Goat
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: None
Constituents: PBS
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Form
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Liquid
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Concentration
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0.100 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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Do not store in frost-free freezer.
Endotoxin level is < 15 ng/mg antibody as determined by the LAL (Limulus amebocyte lysate) method.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CD147 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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References for CD147 antibody (ab11572)
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This product has been used in:
Kirwan RP et al. Influence of cyclical mechanical strain on extracellular matrix gene expression in human lamina cribrosa cells in vitro. Mol Vis 11:798-810 (2005). PubMed: 16205625
If you publish research using ab11572 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to CD147
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CD147 antibody - more information
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