CD15 antibody [VIM-C6] (ab15614)

Product Name 

CD15 antibody [VIM-C6]

Product type 

Primary antibodies

Description 

Mouse monoclonal [VIM-C6] to CD15

Immunogen 

Unfortunately, this information is considered to be commercially sensitive

Reacts with 
(species key)

Hu

Tested applications 
(see key)

Flow Cyt, IHC-Fr

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
Flow Cyt: Use at a concentration of 10 µg/ml.
IHC-Fr: Use at a concentration of 0.5 µg/ml.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Golgi apparatus, Golgi stack membrane; Type II membrane protein. Membrane bound form in trans cisternae of Golgi.

Research areas 

Stem Cells >> Endothelial Progenitors >> Endothelial Markers
Cancer >> Tumor immunology >> CD markers
Stem Cells >> Hematopoietic Progenitors >> Hematopoietic Stem Cells >> Human Lineage Negative
Immunology >> Cell Type Markers >> CD >> Adhesion
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated

Relevance 

The CD15 antigen is expressed on approximately 90% human circulating granulocytes (membranes and granules), 30 to 60% of circulating monocytes and is absent from normal lymphocytes. CD15 antigen is also expressed on Reed Sternberg cells of Hodgkin's disease, on T cell lymphomas including mycosis fungoides and on some leukemias. Outside the hematopoietic system, CD15 expression is described in certain normal and neoplastic epithelial cells and in astrocytes. At least 5 major CD15 antigens (105, 135, 165, 185, 220 kDa) are present on the surface membranes of polymorphonuclear cells. The hapten occurs also in glycolipids. CD15 plays a role in mediating phagocytosis, bactericidal activity and chemotaxis.

ab15614 is directly cytotoxic with rabbit complement

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

VIM-C6

Isotype 

IgM

Purity 

Purified IgM

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: PBS, 10mg/ml BSA. pH 7.2

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.200 mg/ml

Storage instructions 

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

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