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Products:Immunology >> Cell Type Markers >> CD >> NK Cells
Overview
Product name
Anti-CD16 antibody [G7]
See all CD16 products (40) ...
Description
Mouse monoclonal [G7] to CD16
Tested applications
Flow Cyt, IPmore details
Cross reactivity
Reacts with
Pig
Immunogen
Peripheral blood leucocytes (Pig)
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Concentration
Concentration information loading...
Purity
Protein G purified
Primary antibody notes
Clone G7 has been reported to block PBL mediated antibody-dependent cell cytotoxicity (ADCC) and partially inhibit PMN-mediated ADCC.
Clonality
Monoclonal
Clone number
G7
Myeloma
P3x63-Ag8.653
Isotype
IgG1
Research areas
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Neutrophil Lineage
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Monocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> NK Cell Lineage
Stem Cells >> Hematopoietic Progenitors >> Hematopoietic Stem Cells >> Human Lineage Negative
Immunology >> Cell Type Markers >> CD >> NK Cells
Applications
Show applications key
Our Abpromise guarantee covers the use of ab34111 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
IP
Application notes
Flow Cyt: Use 10µl for 106 cells in 100ul.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
Tissue specificity
Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.
Sequence similarities
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Post-translational
modifications
Glycosylated. Contains high mannose- and complex-type oligosaccharides.
The soluble form is produced by a proteolytic cleavage.
Cellular localization
Cell membrane. Secreted. Exists also as a soluble receptor.
Target information above from: UniProt accessionP08637
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD 16 antibody
- CD 16a antibody
- CD16A antibody
see all
References for Anti-CD16 antibody [G7] (ab34111)
This product has been referenced in:
- Halloran PJet al. Biochemical characterization of the porcine Fc gamma RIII alpha homologue G7. Cell Immunol 158:400-13 (1994).Read more (PubMed: 7923391) »
- Wierda WGet al. Two distinct porcine natural killer lytic trigger molecules as PNK-E/G7 molecular complex. Cell Immunol 146:270-83 (1993).Read more (PubMed: 8174170) »
See all 3 publications for this product
Publishing research using ab34111? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"