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Anti-CD1a antibody [CD1a007] (ab708)

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Overview

Product name

Anti-CD1a antibody [CD1a007]
See all CD1a products (22) ...

Description

Mouse monoclonal [CD1a007] to CD1a

Specificity

CD1a staining has been shown to be useful in the differentiation of Langerhans cells from interdigitating cells. It has also proved useful for phenotyping Langerhans cell histiocytosis.

Tested applications

IHC-P, IHC-Frmore details

Cross reactivity

Reacts with

Human

Immunogen

Prokaryotic recombinant fusion protein corresponding to the external portion of the CD1a molecule

Positive control

Skin or tonsil

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: Proprietary, not sodium azide or thimerosal.
Constituents: PBS, Tissue Culture Supernatant. pH 7.3; Protein carrier.

Concentration

Concentration information loading...

Clonality

Monoclonal

Clone number

CD1a007

Myeloma

unknown

Isotype

IgG1

Light chain type

unknown

Research areas

Immunology >> Adaptive Immunity >> T Cells >> CD

  • Immunohistochemistry (Frozen sections) - CD1a antibody [CD1a007] (ab708)Immunohistochemistry (Frozen sections) - CD1a antibody [CD1a007] (ab708) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab708 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Tissue specificity

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Cellular localization

Cell membrane. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.

Target information above from: UniProt accessionP06126 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CD 1a antibody
  • CD1 antibody
  • CD1a antibody
  • CD1A antibody
  • CD1A Antigen antibody
  • CD1A antigen, a polypeptide antibody
  • CD1a molecule antibody
  • CD1A_HUMAN antibody
  • cluster of differentiation 1 A antibody
  • Cortical thymocyte antigen CD1A antibody
  • differentiation antigen CD1 alpha 3 antibody
  • Epidermal dendritic cell marker CD1a antibody
  • FCB 6 antibody
  • FCB6 antibody
  • HTA 1 antibody
  • HTA1 antibody
  • hTa1 thymocyte antigen antibody
  • OTTHUMP00000018907 antibody
  • R 4 antibody
  • R4 antibody
  • T 6 antibody
  • T Cell Surface Antigen Leu 6 antibody
  • T Cell Surface Antigen T6 antibody
  • T cell surface antigen T6/Leu 6 antibody
  • T Cell Surface Glycoprotein CD1A antibody
  • T-cell surface antigen T6/Leu-6 antibody
  • T-cell surface glycoprotein CD1a antibody
  • T6 antibody
  • Thymocyte Antigen CD1A antibody
see all

Database links

Anti-CD1a antibody [CD1a007] images:

  Immunohistochemistry (Frozen sections) - CD1a antibody [CD1a007] (ab708)

Immunohistochemistry (Frozen sections) - CD1a antibody [CD1a007] (ab708)

Ab708 positively staining acetone fixed, frozen human skin sections (1/25).

The secondary Ab used was biotin conjugated anti mouse (1/1) and formed part of of a commercially available kit (Vector labs RTU ABC kit).

This image is courtesy of an Abreview submitted on 11 October 2005. We do not have any further information relating to this image.

References for Anti-CD1a antibody [CD1a007] (ab708)

This product has been referenced in:

  • Mazal PRet al. Langerhans cell histiocytosis of the hypothalamus: diagnostic value of immunohistochemistry. Clin Neuropathol 15:87-91 (1996).Read more (PubMed: 8925602) »
  • Fivenson DP & Nickoloff BJ Distinctive dendritic cell subsets expressing factor XIIIa, CD1a, CD1b and CD1c in mycosis fungoides and psoriasis. J Cutan Pathol 22:223-8 (1995).Read more (PubMed: 7593815) »

See all 3 publications for this product

Publishing research using ab708? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"