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Anti-CD1a antibody [NA1/34-HLK] (ab24055)

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Overview

Product name

Anti-CD1a antibody [NA1/34-HLK]
See all CD1a products (22) ...

Description

Mouse monoclonal [NA1/34-HLK] to CD1a

Specificity

ab24055 recognises the human CD1a cell surface glycoprotein, a 49kD molecule expressed in association with beta 2 microglobulin. CD1a is expressed strongly by cortical thymocytes, and also by Langerhans cells and interdigitating cells. NA1/34 does not precipitate out B2m, and SDS PAGE experiments performed by McMichael, A.J.et al.(1979) suggest that NA1/34 recognises a single protein component. From this information it seems very likely that the epitope is not found on the B2m part of the protein.

Tested applications

Flow Cytmore details

Cross reactivity

Reacts with

Dog, Human, Monkey

Immunogen

Thymocytes (Human).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.4

Concentration

Concentration information loading...

Purity

IgG fraction

Purification notes

Purified IgG prepared by ion exchange chromatography

Clonality

Monoclonal

Clone number

NA1/34-HLK

Myeloma

NS1/1-Ag4-1

Isotype

IgG2a

Research areas

Immunology >> Adaptive Immunity >> T Cells >> CD

Applications

Show applications key

Our Abpromise guarantee covers the use of ab24055 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    Flow Cyt

      See more...Read more →

    Flow Cyt: 1/50 - 1/100.(Use 10 µl of this concentration to label 106 cells in 100µl.)

Target

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Tissue specificity

Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Cellular localization

Cell membrane. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.

Target information above from: UniProt accessionP06126 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • A1 domain antibody
  • CD 1a antibody
  • CD1 antibody
  • CD1A antibody
  • CD1A Antigen antibody
  • CD1A Antigen antibody
  • CD1A antigen, a polypeptide antibody
  • CD1a molecule antibody
  • CD1A_HUMAN antibody
  • CD1b antigen antibody
  • CD1C antigen antibody
  • Cd1d1 antibody
  • cluster of differentiation 1 A antibody
  • Cortical thymocyte antigen CD1A antibody
  • differentiation antigen CD1 alpha 3 antibody
  • Epidermal dendritic cell marker CD1a antibody
  • FCB 6 antibody
  • FCB6 antibody
  • HTA 1 antibody
  • HTA1 antibody
  • hTa1 thymocyte antigen antibody
  • Ly38 antibody
  • OTTHUMP00000018907 antibody
  • R 4 antibody
  • R4 antibody
  • T 6 antibody
  • T Cell Surface Antigen Leu 6 antibody
  • T Cell Surface Antigen T6 antibody
  • T cell surface antigen T6/Leu 6 antibody
  • T Cell Surface Glycoprotein CD1A antibody
  • T-cell surface antigen T6/Leu-6 antibody
  • T-cell surface glycoprotein CD1a antibody
  • T6 antibody
  • T6/Leu6 antibody
  • Thymocyte Antigen CD1A antibody
  • Thymocyte Antigen CD1A antibody
see all

References for Anti-CD1a antibody [NA1/34-HLK] (ab24055)

This product has been referenced in:

  • Yoshino Net al. Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies. Exp Anim 49:97-110 (2000).Read more (PubMed: 10889948) »
  • Galkowska Het al. Reactivity of antibodies directed against human antigens with surface markers on canine leukocytes. Vet Immunol Immunopathol 53:329-34 (1996).Read more (PubMed: 8969052) »

See all 4 publications for this product

Publishing research using ab24055? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"