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Products:Immunology >> Adaptive Immunity >> T Cells >> CD
Overview
Product name
Anti-CD1a antibody [NA1/34] (Phycoerythrin)
See all CD1a products (22) ...
Description
Mouse monoclonal [NA1/34] to CD1a (Phycoerythrin)
Conjugation
Phycoerythrin
Specificity
ab222352 recognises specifically CD1a expressed by human cortical thymocytes, Langerhans cells, Dendritic cells and a subset of B cells.
Tested applications
Flow Cytmore details
Cross reactivity
Reacts with
Human, Cynomolgus Monkey
Immunogen
Tissue / cell preparation (Human): Fresh human thymocytes
General notes
Recommended negative control: Mouse IgG2a Negative Control
Properties
Form
Liquid
Storage instructions
Store at +4°C in the dark. Do not freeze.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 1% BSA, PBS, pH 7.2
Concentration
Concentration information loading...
Purification notes
Purified IgG prepared by ion exchange chromatography
Clonality
Monoclonal
Clone number
NA1/34
Myeloma
NS1/1-Ag4-1
Isotype
IgG2a
Research areas
Immunology >> Adaptive Immunity >> T Cells >> CD
Applications
Show applications key
Our Abpromise guarantee covers the use of ab22352 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
Application notes
Flow Cyt: Use 10µl for 106 cells in 100µl.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Tissue specificity
Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
Sequence similarities
Contains 1 Ig-like (immunoglobulin-like) domain.
Cellular localization
Cell membrane. Endosome membrane. Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts.
Target information above from: UniProt accessionP06126
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD 1a antibody
- CD1 antibody
- CD1a antibody
see all
Database links
- Entrez Gene: 909 Human
- Omim: 188370 Human
- SwissProt: P06126 Human
- Unigene: 1309 Human
References for Anti-CD1a antibody [NA1/34] (Phycoerythrin) (ab22352)
This product has been referenced in:
- de Jong MAet al. Mutz-3-derived Langerhans cells are a model to study HIV-1 transmission and potential inhibitors. J Leukoc Biol 87:637-43 (2010).Read more (PubMed: 20042470) »
- de Jong MAet al. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol 185:1633-41 (2010).Read more (PubMed: 20592277) »
See all 2 publications for this product
Publishing research using ab22352? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"