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Products:Immunology >> Cell Type Markers >> CD >> Non-lineage
Overview
Product name
Anti-CD274 antibody, prediluted
See all CD274 products (9) ...
Description
Rabbit polyclonal to CD274, prediluted
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Human
Immunogen
A synthetic peptide corresponding to near the N terminal of human CD274
Positive control
Human lung and skeletal muscle
Properties
Form
Prediluted
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 50mM Tris, pH 7.6
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Immune System Diseases >> Autoimmune
Immunology >> Cell Type Markers >> CD >> Non-lineage
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD274 antibody (ab82059)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab82059 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use at an assay dependent dilution. (Ready to useBoil tissue section in 10mM Citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.)
Target
Function
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Tissue specificity
Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Sequence similarities
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localization
Cell membrane and Endomembrane system.
Target information above from: UniProt accessionQ9NZQ7
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- B7 H1 antibody
- B7 homolog 1 antibody
- PD L1 antibody
see all
Database links
- Entrez Gene: 29126 Human
- Omim: 605402 Human
- SwissProt: Q9NZQ7 Human
- Unigene: 521989 Human
Anti-CD274 antibody, prediluted images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD274 antibody (ab82059)
ab82059, at 1/100 dilution, staining of Formalin-fixed, paraffin-embedded, human lung tissue using Immunohistochemistry
References for Anti-CD274 antibody, prediluted (ab82059)
This product has been referenced in:
- Loos Met al. Clinical significance of the costimulatory molecule B7-H1 in Barrett carcinoma. Ann Thorac Surg 91:1025-31 (2011). IHC-P.Read more (PubMed: 21440117) »
See 1 publication for this product
Publishing research using ab82059? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"