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Product name
Anti-CD3 antibody [UCHT1] (Allophycocyanin), prediluted
See all CD3 products (79) ...
Description
Mouse monoclonal [UCHT1] to CD3, prediluted (Allophycocyanin)
Conjugation
Allophycocyanin
Specificity
ab106224 recognizes the CD3 antigen of the TCR/CD3 complex on mature Human T cells. It reacts with the epsilon chain of the CD3 complex. HLDA I; WS Code T 3 HLDA III; WS Code T 126 HLDA III; WS Code T 471 HLDA VI; WS Code T 6T-CD3.1
Tested applications
Flow Cytmore details
Cross reactivity
Reacts with
Human, Non Human Primates
Immunogen
Human thymocytes followed by Sezary T cells
Positive control
Human blood cells
Properties
Form
Liquid
Storage instructions
Store at +4°C in the dark. Do not freeze.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: 0.2% BSA, PBS
Concentration
Concentration information loading...
Purity
Size exclusion
Clonality
Monoclonal
Clone number
UCHT1
Isotype
IgG1
Research areas
Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Hematopoietic Stem Cells >> Human Lineage Negative
Immunology >> Adaptive Immunity >> T Cells >> CD
Applications
Show applications key
Our Abpromise guarantee covers the use of ab106224 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use 10µl for 106 cells.
Target
Function
The CD3 complex mediates signal transduction.
Involvement in disease
Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)/B(+)/NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
Sequence similarities
Contains 1 ITAM domain.
Cellular localization
Membrane.
Target information above from: UniProt accessionP04234
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- 4930549J05Rik antibody
- A430104F18Rik antibody
- AW552088 antibody
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Database links
- Entrez Gene: 916 Human
- Entrez Gene: 917 Human
- Entrez Gene: 919 Human
- Entrez Gene: 915 Human
- Omim: 186830 Human
- Omim: 186790 Human
- Omim: 186740 Human
- Omim: 186780 Human
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References for Anti-CD3 antibody [UCHT1] (Allophycocyanin), prediluted (ab106224)
This product has been referenced in:
- Siegers GM et al. Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies. J Exp Med 204:2537-44 (2007).Read more (PubMed: 17923503) »
- Demedts IK et al. Identification and characterization of human pulmonary dendritic cells. Am J Respir Cell Mol Biol 32:177-84 (2005).Read more (PubMed: 15576669) »
See all 6 publications for this product
Publishing research using ab106224? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"