Anti-CD33 antibody [3D6] (ab11031)

Overview

• Product nameAnti-CD33 antibody [3D6]See all CD33 primary antibodies ...
• Description
  Mouse monoclonal [3D6] to CD33
• Tested applicationsELISA more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  CD33-Fc recombinant protein.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: PBS
• Concentration information loading...
• PurityProtein A purified
• Clonality Monoclonal
• Clone number3D6
• MyelomaSp2/0-Ag14
• IsotypeIgG1
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Hematopoietic Stem Cells
  • Human Lineage Negative

  • Immunology
  • Cell Type Markers
  • CD
  • Myeloid Cells

Applications

Target

• FunctionPutative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
• Tissue specificityMonocytic/myeloid lineage cells.
• Sequence similaritiesBelongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
  Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• DomainContains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
• Post-translational
  modificationsPhosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.
• Cellular localizationCell membrane.

Target information above from: UniProt accession P20138 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 945 Human
  • Entrez Gene: 12489 Mouse
  • Omim: 159590 Human
  • SwissProt: P20138 Human
  • SwissProt: Q63994 Mouse
  • Unigene: 83731 Human
  • Unigene: 140157 Mouse

• Alternative names
  CD 33 antibodyCD33 antibodyCD33 antigen (gp67) antibody

  CD33 antigen antibodyCD33 molecule antibodyCD33_HUMAN antibodyFLJ00391 antibodygp67 antibodyMy9 antibodyMyeloid cell surface antigen CD33 antibodyMyeloid cell surface antigen CD33 precursor antibodyp67 antibodySialic acid binding Ig like lectin 3 antibodySialic acid binding immunoglobulin like lectin 3 antibodySialic acid-binding Ig-like lectin 3 antibodySIGLEC 3 antibodySiglec-3 antibodySIGLEC3 antibody

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