Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Cardiovascular >> Blood >> Platelets
Overview
Product name
Anti-CD36 antibody [JC63.1]
See all CD36 products (22) ...
Description
Mouse monoclonal [JC63.1] to CD36
Specificity
ab23680 recognises CD36.
Tested applications
Flow Cyt, Blockingmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Recombinant full length protein (Mouse): adenovirus espressing CD36.
Positive control
Cells from adipose tissue, Heart tissue, platelets and macrophages.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, pH 7.2
Concentration
Concentration information loading...
Clonality
Monoclonal
Clone number
JC63.1
Isotype
IgA
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Metabolism of lipids and lipoproteins
Stem Cells >> Endothelial Progenitors >> Endothelial Markers
Cardiovascular >> Atherosclerosis >> Lipid transport
Stem Cells >> Hematopoietic Progenitors >> Hematopoietic Stem Cells >> Human Lineage Negative
Microbiology >> Protein >> Human Protein >> Defensin
Immunology >> Cell Type Markers >> CD >> Platelets
Cardiovascular >> Blood >> Platelets
Applications
Show applications key
Our Abpromise guarantee covers the use of ab23680 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use a concentration of 0.5 µg/ml
BL: Use a concentration of 2 µg/ml((or 1/500).Note: ab23680 inhibits CD36 binding of ox-LDL (macrophages) and rod puter segments (retinal pigment epithelial cells) and prevents foam cell formation of macrophages.)
Target
Function
Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects.
Involvement in disease
Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].
Sequence similarities
Belongs to the CD36 family.
Post-translational
modifications
N-glycosylated and O-glycosylated with a ratio of 2:1.
Cellular localization
Membrane.
Target information above from: UniProt accessionP16671
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Adipocyte membrane protein antibody
- CD 36 antibody
- CD36 antibody
see all
Database links
- Entrez Gene: 948 Human
- Entrez Gene: 12491 Mouse
- Entrez Gene: 29184 Rat
- Omim: 173510 Human
- SwissProt: P16671 Human
- SwissProt: Q08857 Mouse
- SwissProt: Q07969 Rat
- Unigene: 120949 Human
see all
References for Anti-CD36 antibody [JC63.1] (ab23680)
ab23680 has not yet been referenced specifically in any publications.
Publishing research using ab23680? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"