Anti-CD36 antibody [VM58] (ab8145)
- Product nameAnti-CD36 antibody [VM58]See all CD36 primary antibodies ...
- DescriptionMouse monoclonal [VM58] to CD36
- SpecificityThe monoclonal antibody VM58 is directed against the CD36 antigen, a 90kD glycoprotein, also called GP IIIb expressed on human platelets. The GP IV (GP IIIb) molecule has been shown to function as thrombospondin receptor on platelets and monocytes and as receptor for Plasmodium falciparum infected erythrocytes. The monoclonal antibody reacts with platelets, monocytes, macrophages, erythroblasts and (weakly) with B-cells. In immunohistology the monoclonal antibody reacts with some endothelial cells, adipocytes and the granular layer of the skin. The antibody VM58 induces Fc-receptor-dependent platelet aggregation after binding to platelet. The heterogeneity of the response found in healthy individuals is dependent on the polymorphism of the Fc RII on platelets.
- Tested applicationsIHC-Fr, ICC/IF more details
- Species reactivityReacts with: Human
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPBS & Sodium Azide
- Concentration information loading...
- PurityIgG fraction
- Purification notesAmmonium sulfate + DEAE-cellulose, gradient elution
- Clonality Monoclonal
- Clone numberVM58
- Light chain typekappa
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
Our Abpromise guarantee covers the use of ab8145 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: Use at an assay dependent dilution.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionSeems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects.
- Involvement in diseaseDefects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].
- Sequence similaritiesBelongs to the CD36 family.
modificationsN-glycosylated and O-glycosylated with a ratio of 2:1.
- Cellular localizationMembrane.
- Adipocyte membrane protein antibodyCD 36 antibodyCD36 antibody
- CD36 antibodyCD36 antigen (collagen type I receptor, thrombospondin receptor) antibodycd36 antigen antibodyCD36 molecule (thrombospondin receptor) antibodyCD36 molecule antibodyCD36_HUMAN antibodyCHDS7 antibodyCluster determinant 36 antibodyCollagen receptor, platelet antibodyFAT antibodyfatty acid translocase antibodyFatty acid transport protein antibodyglycoprotein iiib antibodyGP IIIb antibodygp3b antibodygp4 antibodygpiiib antibodygpiv antibodyleukocyte differentiation antigen cd36 antibodyMGC108510 antibodyMGC91634 antibodyPAS 4 protein antibodyPAS IV antibodyPAS-4 antibodypas4 protein antibodypasiv antibodyplatelet collagen receptor antibodyPlatelet glycoprotein 4 antibodyplatelet glycoprotein iv antibodyscarb3 antibodyScavenger receptor class B member 3 antibodythrombospondin receptor antibody
References for Anti-CD36 antibody [VM58] (ab8145)
This product has been referenced in:
- Vinogradov DV et al. [Inhibition of Fc-receptor dependent platelet aggregation by monoclonal antibodies against the glycoprotein IIb-IIIa complex] Biokhimiia 56:787-97 (1991). Read more (PubMed: 1747408) »