![Flow Cytometry - Anti-CD38 antibody [HIT2] (ab2577) image](#CD38-Primary-antibodies-ab2577-4.jpg)
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Products:Immunology >> Adaptive Immunity >> B Cells >> CD
Overview
Product name
Anti-CD38 antibody [HIT2]
See all CD38 products (40) ...
Description
Mouse monoclonal [HIT2] to CD38
Specificity
CD38 antigen
Tested applications
Flow Cyt, IHC-Fr, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Tissue / cell preparation (Human thymocytes in foetus).
Positive control
Cell lines derived from B-cell chronic lymphocytic leukemia (B-CLL).
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
>95% by SDS-PAGE
Purification notes
Purified from ascites by protein G-affinity chromatography.
Clonality
Monoclonal
Clone number
HIT2
Myeloma
unknown
Isotype
IgG1
Light chain type
unknown
Research areas
Cancer >> Cancer Metabolism >> Response to hypoxia
Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Monocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> NK Cell Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Stem Cells >> Hematopoietic Progenitors >> Hematopoietic Stem Cells >> Human Lineage Negative
Immunology >> Adaptive Immunity >> B Cells >> CD
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Flow Cytometry - Anti-CD38 antibody [HIT2] (ab2577)
![Flow Cytometry - Anti-CD38 antibody [HIT2] (ab2577) image](/ps/datasheet/images/2/ab2577/CD38-Primary-antibodies-ab2577-4.jpg)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab2577 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr
WB
Application notes
Flow Cyt: Use at an assay dependant concentration.
IHC-Fr: Use at an assay dependant concentration.
WB: Use at an assay dependant concentration. Use under non-reducing conditions.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Tissue specificity
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Sequence similarities
Belongs to the ADP-ribosyl cyclase family.
Developmental stage
Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
Cellular localization
Membrane.
Target information above from: UniProt accessionP28907
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Form
There are 2 isoforms produced by alternative splicing.
Alternative names
- Acute lymphoblastic leukemia cells antigen CD38 antibody
- ADP ribosyl cyclase 1 antibody
- ADP ribosyl cyclase antibody
see all
Database links
- Entrez Gene: 952 Human
- Omim: 107270 Human
- SwissProt: P28907 Human
- Unigene: 479214 Human
Anti-CD38 antibody [HIT2] images:
Flow Cytometry - Anti-CD38 antibody [HIT2] (ab2577)
Flow cytometry analysis of human peripheral blood leukocytes with anti-human CD38 (HIT2) purified.
References for Anti-CD38 antibody [HIT2] (ab2577)
This product has been referenced in:
- Joshua Det al. The labelling index of primitive plasma cells determines the clinical behaviour of patients with myelomatosis. Br J Haematol 94:76-81 (1996).Read more (PubMed: 8757512) »
- Schlossman (Eds.) et al. Leucocyte typing V. Oxford University Press : (1995).Read more (PubMed: ) »
See all 4 publications for this product
Publishing research using ab2577? Please let us know so that we can cite the reference in this datasheet
![CD38 antibody [HIT2] for Flow Cytometry in Human (2577)](/ps/datasheet/images/2/ab2577/CD38-Primary-antibodies-ab2577-2.jpg)
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"