Anti-CD4 antibody [1F6], prediluted (ab17131)
- Product nameAnti-CD4 antibody [1F6], predilutedSee all CD4 primary antibodies ...
- DescriptionMouse monoclonal [1F6] to CD4, prediluted
- Tested applicationsIHC-Fr, IHC-P more details
- Species reactivityReacts with: Human
Synthetic peptide (corresponding to the external domain of Human CD4).
- Positive control
- Storage instructionsStore at +4°C.
- Storage bufferPreservative: 0.05% Sodium Azide
Constituents: Inert stabilizer
- Concentration information loading...
- PurityTissue culture supernatant
- Clonality Monoclonal
- Clone number1F6
Our Abpromise guarantee covers the use of ab17131 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-Fr||IHC-Fr: Use at an assay dependent dilution. Fix with acetone.|
|IHC-P||IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
- FunctionAccessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
- Sequence similaritiesContains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
modificationsPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
- Cellular localizationCell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
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- CD4+ Lymphocyte deficiency, included antibody
- CD4_HUMAN antibody
- CD4mut antibody
- L3T4 antibody
- Leu3 antibody
- Ly-4 antibody
- Lymphocyte antigen CD4 antibody
- MGC165891 antibody
- OTTHUMP00000238897 antibody
- p55 antibody
- T Cell Antigen T4 antibody
- T cell antigen T4/LEU3 antibody
- T cell differentiation antigen L3T4 antibody
- T cell OKT4 deficiency, included antibody
- T cell surface antigen T4/Leu 3 antibody
- T Cell Surface Antigen T4/Leu3 antibody
- T cell surface antigen T4/Leu3 antibody
- T Cell Surface Glycoprotein CD4 antibody
- T-cell surface antigen T4/Leu-3 antibody
- T-cell surface glycoprotein CD4 antibody
- W3/25 antibody
- W3/25 antigen antibody
References for Anti-CD4 antibody [1F6], prediluted (ab17131)
This product has been referenced in:
- Callahan MJ et al. Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer. Clin Cancer Res 14:7667-73 (2008). IHC-P ; Human . Read more (PubMed: 19047092) »