Post-translational modificationsPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localizationCell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
References for Anti-CD4 antibody [CT-4] (FITC) (ab24896)
This product has been referenced in:
Jakka P et al. Evaluation of immune responses by live infectious bursal disease vaccines to avoid vaccination failures. Eur J Microbiol Immunol (Bp)4:123-7 (2014).
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