SpecificityRecognises the feline homologue of the human CD4 antigen. This antibody does not recognise CD4 in a small number of cats, and is therefore likely to recognise a polymorphic epitope. CD4 is not expressed on feline monocytes.
Post-translational modificationsPalmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular localizationCell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
References for Anti-CD4 antibody [vpg 39] (ab23504)
This product has been referenced in:
Willett BJ et al. The generation of monoclonal antibodies recognising novel epitopes by immunisation with solid matrix antigen-antibody complexes reveals a polymorphic determinant on feline CD4. J Immunol Methods176:213-20 (1994).
Read more (PubMed: 7527069) »