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Products:Immunology >> Adaptive Immunity >> B Cells >> CD
Overview
Product name
Anti-CD40 antibody [1C10]
See all CD40 products (42) ...
Description
Rat monoclonal [1C10] to CD40
Specificity
ab25298 recognises CD40.
Tested applications
Flow Cyt, IP, Functional Studiesmore details
Cross reactivity
Reacts with
Mouse
Immunogen
The details of the immunogen for this antibody are not available.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 100mM Borate buffered saline, pH 8.2
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Monoclonal
Clone number
1C10
Isotype
IgG2a
Light chain type
kappa
Research areas
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Dendritic Cell Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Innate and adaptive immunity
Immunology >> Adaptive Immunity >> B Cells >> CD
Applications
Show applications key
Our Abpromise guarantee covers the use of ab25298 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
IP
Functional Studies
Application notes
Flow Cyt: Use at an assay dependent dilution.
FuncS (in vitro induction of proliferation of mature B lymphocytes): Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Receptor for TNFSF5/CD40LG.
Tissue specificity
B-cells and in primary carcinomas.
Involvement in disease
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
Sequence similarities
Contains 4 TNFR-Cys repeats.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionP25942
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Tumor necrosis factor receptor superfamily , member 5 antibody
- AI326936 antibody
- B cell associated molecule CD40 antibody
see all
Database links
- Entrez Gene: 21939 Mouse
- SwissProt: P27512 Mouse
- SwissProt: Q8K2X6 Mouse
- Unigene: 271833 Mouse
References for Anti-CD40 antibody [1C10] (ab25298)
This product has been referenced in:
- Heath AWet al. Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur J Immunol 24:1828-34 (1994).Read more (PubMed: 7519997) »
See 1 publication for this product
Publishing research using ab25298? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"