Anti-CD40 antibody [3/23] (ab22469)

Overview

• Product nameAnti-CD40 antibody [3/23]See all CD40 primary antibodies ...
• Description
  Rat monoclonal [3/23] to CD40
• SpecificityDoes not react with normal mouse Ig or with human IgG1 and will stain most mature mouse B cells. Does not cross react with mouse T cells. ab22469 is a powerful activator of normal B cells especially in the presence of IL4.
• Tested applicationsELISA, Flow Cyt, IHC-Fr more details
• Species reactivity
  Reacts with: Mouse, Human
  
• Immunogen

  Extracellular Domain of Mouse CD40 and the Fc portion of Human IgG1.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• PurityProtein G purified
• Clonality Monoclonal
• Clone number3/23
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Dendritic Cell Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • B Lymphocytic Lineage

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Innate and adaptive immunity

  • Immunology
  • Adaptive Immunity
  • B Cells
  • CD

Applications

Target

• FunctionReceptor for TNFSF5/CD40LG.
• Tissue specificityB-cells and in primary carcinomas.
• Involvement in diseaseDefects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
• Sequence similaritiesContains 4 TNFR-Cys repeats.
• Cellular localizationSecreted and Cell membrane.

Target information above from: UniProt accession P25942 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 958 Human
  • Entrez Gene: 21939 Mouse
  • Omim: 109535 Human
  • SwissProt: P25942 Human
  • SwissProt: P27512 Mouse
  • Unigene: 472860 Human
  • Unigene: 271833 Mouse

• Alternative names
  AI326936 antibodyB cell associated molecule CD40 antibodyB cell surface antigen CD40 antibody

  B cell-associated molecule antibodyB-cell surface antigen CD40 antibodyBp50 antibodyCD 40 antibodyCD40 antibodyCD40 antibodyCD40 antigen (TNF receptor superfamily member 5) antibodyCD40 antigen antibodyCD40 molecule antibodyCD40 molecule, TNF receptor superfamily member 5 antibodyCD40 protein antibodyCD40 type II isoform antibodyCD40L receptor antibodyCDw40 antibodyGP39 antibodyHIGM1 antibodyIGM antibodyIMD3 antibodyMGC9013 antibodyNerve growth factor receptor related B lymphocyte activation molecule antibodyOTTHUMP00000031699 antibodyOTTHUMP00000031700 antibodyp50 antibodyT-BAM antibodyTBAM antibodyTNF receptor superfamily member 5 antibodyTNFRSF5 antibodyTNFRSF5 antibodyTNR5_HUMAN antibodyTRAP antibodyTumor necrosis factor receptor superfamily , member 5 antibodyTumor necrosis factor receptor superfamily member 5 antibodyTumor necrosis factor receptor superfamily member 5 precursor antibodyTumor necrosis factor receptor superfamily, member 5, isoform CRA_a antibody

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Anti-CD40 antibody [3/23] images

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  Flow Cytometry - CD40 antibody [3/23] (ab22469)
  ab22469 staining CD40 in Mouse Spleen cells by flow cytometric analysis.