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Overview

  • Product nameAnti-CD40 antibody [HM40-3]See all CD40 primary antibodies ...
  • Description
    Armenian Hamster monoclonal [HM40-3] to CD40
  • Tested applicationsFlow Cyt more details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    (BALB/c x NZB) F1 mouse-derived lymphoma WEHI-231 cells.

  • Positive controlMouse BALB/c splenocytes

Properties

Applications

Our Abpromise guarantee covers the use of ab95533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt Flow Cyt: Use 0.5-1µg for 105-8 cells. Staining the cell sample in a final volume of 100µl is recommended.

Target

  • FunctionReceptor for TNFSF5/CD40LG.
  • Tissue specificityB-cells and in primary carcinomas.
  • Involvement in diseaseDefects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
  • Sequence similaritiesContains 4 TNFR-Cys repeats.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession P25942 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        AI326936 antibodyB cell associated molecule CD40 antibodyB cell surface antigen CD40 antibody
        B cell-associated molecule antibodyB-cell surface antigen CD40 antibodyBp50 antibodyCD 40 antibodyCD40 antibodyCD40 antibodyCD40 antigen (TNF receptor superfamily member 5) antibodyCD40 antigen antibodyCD40 molecule antibodyCD40 molecule, TNF receptor superfamily member 5 antibodyCD40 protein antibodyCD40 type II isoform antibodyCD40L receptor antibodyCDw40 antibodyGP39 antibodyHIGM1 antibodyIGM antibodyIMD3 antibodyMGC9013 antibodyNerve growth factor receptor related B lymphocyte activation molecule antibodyOTTHUMP00000031699 antibodyOTTHUMP00000031700 antibodyp50 antibodyT-BAM antibodyTBAM antibodyTNF receptor superfamily member 5 antibodyTNFRSF5 antibodyTNR5_HUMAN antibodyTRAP antibodyTumor necrosis factor receptor superfamily , member 5 antibodyTumor necrosis factor receptor superfamily member 5 antibodyTumor necrosis factor receptor superfamily member 5 precursor antibodyTumor necrosis factor receptor superfamily, member 5, isoform CRA_a antibody
      see all

    Anti-CD40 antibody [HM40-3] images

    • Flow Cytometry - CD40 antibody [HM40-3] (ab95533)
      Flow Cytometry - CD40 antibody [HM40-3] (ab95533)
      Flow cytometry staining of BALB/c splenocytes with 0.5 µg Armenian Hamster IgG Isotype Control (open histogram) or 0.5 µg ab95533 (filled histogram) followed by Anti-Armenian Hamster IgG FITC. Total viable cells were used for analysis.

    References for Anti-CD40 antibody [HM40-3] (ab95533)

    This product has been referenced in:
    • Inaba K  et al. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J Exp Med 180:1849-60 (1994). Read more (PubMed: 7525841) »

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