Overview

  • Product nameAnti-CD40 antibody [MAB89]See all CD40 primary antibodies ...
  • Description
    Mouse monoclonal [MAB89] to CD40
  • Tested applicationsFlow Cyt, Functional Studies, Cellular activationmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Anti-mu activated tonsillar human B cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab19684 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
Functional Studies
Cellular activation
  • Application notesCellular activation: Use at a concentration of 10 ng/ml.
    Flow Cyt: Use 2µg for 5X105 cells.
    FuncS: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for TNFSF5/CD40LG.
    • Tissue specificityB-cells and in primary carcinomas.
    • Involvement in diseaseDefects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
    • Sequence similaritiesContains 4 TNFR-Cys repeats.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • AI326936 antibody
      • B cell associated molecule CD40 antibody
      • B cell surface antigen CD40 antibody
      • B cell-associated molecule antibody
      • B-cell surface antigen CD40 antibody
      • Bp50 antibody
      • CD 40 antibody
      • CD40 antibody
      • CD40 antibody
      • CD40 antigen (TNF receptor superfamily member 5) antibody
      • CD40 antigen antibody
      • CD40 molecule antibody
      • CD40 molecule, TNF receptor superfamily member 5 antibody
      • CD40 protein antibody
      • CD40 type II isoform antibody
      • CD40L receptor antibody
      • CDw40 antibody
      • GP39 antibody
      • HIGM1 antibody
      • IGM antibody
      • IMD3 antibody
      • MGC9013 antibody
      • Nerve growth factor receptor related B lymphocyte activation molecule antibody
      • OTTHUMP00000031699 antibody
      • OTTHUMP00000031700 antibody
      • p50 antibody
      • T-BAM antibody
      • TBAM antibody
      • TNF receptor superfamily member 5 antibody
      • TNFRSF5 antibody
      • TNFRSF5 antibody
      • TNR5_HUMAN antibody
      • TRAP antibody
      • Tumor necrosis factor receptor superfamily , member 5 antibody
      • Tumor necrosis factor receptor superfamily member 5 antibody
      • Tumor necrosis factor receptor superfamily member 5 precursor antibody
      • Tumor necrosis factor receptor superfamily, member 5, isoform CRA_a antibody
      see all

    References for Anti-CD40 antibody [MAB89] (ab19684)

    This product has been referenced in:
    • Ornatsky O  et al. Highly multiparametric analysis by mass cytometry. J Immunol Methods 361:1-20 (2010). Flow Cyt ; Human . Read more (PubMed: 20655312) »
    • Rousset F  et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89:1890-3 (1992). Read more (PubMed: 1371884) »

    See all 2 Publications for this product

    Product Wall

    Thank you for contacting us.

    I can confirm that the product was sterile when we dispatched it to you. It is fully guaranteed and is suitable for use in Flow Cyt, Functional Studies, Cellular activation.

    I hope this information is ...

    Read More

    Thank you for your enquiry. The "activation" information came from the following published reference. The paper discusses activation of B cells. http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=48559&blobtype=pdf I have also added a link...

    Read More

    Thank you for your enquiry. Mouse monoclonal [MAB89] to CD40 (ab19684) was characterized as part of the Leucocyte Workshop VI. Testing was done by IHC (frozen sections), Western blot, and functional studies. There are several published referenc...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"