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Products:Immunology >> Adaptive Immunity >> B Cells >> CD
Overview
Product name
Anti-CD40 antibody [MAB89]
See all CD40 products (42) ...
Description
Mouse monoclonal [MAB89] to CD40
Tested applications
Flow Cyt, Functional Studies, Cellular activationmore details
Cross reactivity
Reacts with
Human
Immunogen
Anti-mu activated tonsillar human B cells.
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: None
Constituents: Lyophilized from: PBS, 1mg/ml BSA
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Monoclonal
Clone number
MAB89
Myeloma
NS1
Isotype
IgG1
Research areas
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Dendritic Cell Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Innate and adaptive immunity
Immunology >> Adaptive Immunity >> B Cells >> CD
Applications
Show applications key
Our Abpromise guarantee covers the use of ab19684 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt
Functional Studies
Cellular activation
Application notes
Cellular activation: Use at a concentration of 10 ng/ml.
Flow Cyt: Use 2µg for 5X105 cells.
FuncS: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Receptor for TNFSF5/CD40LG.
Tissue specificity
B-cells and in primary carcinomas.
Involvement in disease
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
Sequence similarities
Contains 4 TNFR-Cys repeats.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionP25942
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Tumor necrosis factor receptor superfamily , member 5 antibody
- AI326936 antibody
- B cell associated molecule CD40 antibody
see all
Database links
- Entrez Gene: 958 Human
- Omim: 109535 Human
- SwissProt: P25942 Human
- Unigene: 472860 Human
References for Anti-CD40 antibody [MAB89] (ab19684)
This product has been referenced in:
- Ornatsky Oet al. Highly multiparametric analysis by mass cytometry. J Immunol Methods 361:1-20 (2010). Flow Cyt; Human.Read more (PubMed: 20655312) »
- Rousset Fet al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A 89:1890-3 (1992).Read more (PubMed: 1371884) »
See all 2 publications for this product
Publishing research using ab19684? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"