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Products:Immunology >> Adaptive Immunity >> B Cells >> CD
Overview
Product name
Anti-CD40 antibody
See all CD40 products (42) ...
Description
Rabbit polyclonal to CD40
Tested applications
IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
A synthetic peptide derived from C terminal of human CD40.
Positive control
IHC-P: Human tonsil.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 0.2% BSA, PBS, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Dendritic Cell Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Innate and adaptive immunity
Immunology >> Adaptive Immunity >> B Cells >> CD
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Immunohistochemistry (Formalin/PFA fixed sections) - CD40 antibody (ab58612)
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Applications
Show applications key
Our Abpromise guarantee covers the use of ab58612 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: 1/100Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
Target
Function
Receptor for TNFSF5/CD40LG.
Tissue specificity
B-cells and in primary carcinomas.
Involvement in disease
Defects in CD40 are the cause of hyper-IgM immunodeficiency syndrome type 3 (HIGM3) [MIM:606843]; also known as hyper-IgM syndrome 3. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.
Sequence similarities
Contains 4 TNFR-Cys repeats.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionP25942
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Tumor necrosis factor receptor superfamily , member 5 antibody
- AI326936 antibody
- B cell associated molecule CD40 antibody
see all
Database links
- Entrez Gene: 958 Human
- Entrez Gene: 21939 Mouse
- Entrez Gene: 171369 Rat
- Omim: 109535 Human
- SwissProt: P25942 Human
- SwissProt: P27512 Mouse
- SwissProt: Q8K2X6 Mouse
- SwissProt: Q4QQW2 Rat
see all
Anti-CD40 antibody images:
Immunohistochemistry (Formalin/PFA fixed sections) - CD40 antibody (ab58612)
ab58612, at 1/100 dilution, staining CD40 in formalin fixed human tonsil tissue by Immunohistochemistry.
References for Anti-CD40 antibody (ab58612)
ab58612 has not yet been referenced specifically in any publications.
Publishing research using ab58612? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"