You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Anti-CD41/Integrin alpha 2b antibody [M148] (FITC) (ab19708)

Submit an Abreview Submit a Question

Overview

  • Product nameAnti-CD41/Integrin alpha 2b antibody [M148] (FITC)See all CD41/Integrin alpha 2b primary antibodies ...
  • Description
    Mouse monoclonal [M148] to CD41/Integrin alpha 2b (FITC)
  • ConjugationFITC
  • SpecificityRecognizes an epitope on the gpIIb/IIIa complex on the surface membrane of human platelets.
  • Tested applicationsFlow Cyt more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human mededulloblastoma tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab19708 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt Flow Cyt: Use 1µg for 106 cells.

Target

  • FunctionIntegrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
  • Tissue specificityIsoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
  • Involvement in diseaseDefects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
  • Sequence similaritiesBelongs to the integrin alpha chain family.
    Contains 7 FG-GAP repeats.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P08514 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        antigen CD41 antibodyBDPLT2 antibodyCD41 antibody
        cd41 antigen antibodyCD41a antibodycd41b antibodyform 2 antibodygp2b antibodyGPalpha IIb antibodygpalphaiib antibodygpiib antibodyGT antibodygta antibodyHPA3 antibodyIntegrin alpha 2b antibodyIntegrin alpha IIb antibodyIntegrin alpha-IIb light chain antibodyITA2B_HUMAN antibodyITGA2B antibodyITGAB antibodyplatelet fibrinogen receptor alpha antibodyplatelet fibrinogen receptor, alpha subunit antibodyplatelet glycoprotein IIb of IIb/IIIa complex antibodyplatelet membrane glycoprotein iib antibodyplatelet specific antigen bak antibody
      see all

    References for Anti-CD41/Integrin alpha 2b antibody [M148] (FITC) (ab19708)

    ab19708 has not yet been referenced specifically in any publications.

    Publishing research using ab19708 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab19708 Submit a Question for ab19708

    There are currently no Abreviews or Questions for ab19708.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"