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Products:Cardiovascular >> Blood >> Platelets
Overview
Product name
Anti-CD42b antibody [VM16d]
See all CD42b products (17) ...
Description
Mouse monoclonal [VM16d] to CD42b
Tested applications
ICC/IF, Functional Studiesmore details
Cross reactivity
Reacts with
Human
Immunogen
Tissue / cell preparation containing human CD42b glycoprotein.
Epitope
The epitope is located within the 45 kDa N-terminal domain of GPIb alpha- chain.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purification notes
Ammonium sulfate + DEAE-cellulose, gradient elution
Primary antibody notes
This antibody inhibits low conc. thrombin (<0.1 U/ml) induced platelet aggregation and decreases thrombin binding to platelets. F(ab')2 and F(ab') fragments are equally effective as whole intact antibodies. It does not affect platelet interaction with von Willebrand factor, leading to the conclusion that the antibody reacts with or nearby the thrombin receptor site.
Clonality
Monoclonal
Clone number
VM16d
Isotype
IgG1
Light chain type
kappa
Research areas
Immunology >> Cell Type Markers >> CD >> Platelets
Cardiovascular >> Blood >> Platelets
Applications
Show applications key
Our Abpromise guarantee covers the use of ab34408 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF: Use at an assay dependent dilution.
FuncS: Use at an assay dependent dilution.
Target
Relevance
CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. Its expression and activation seems to be regulated by VEGF and PDGF.
Cellular localization
Cell Membrane
Alternative names
- Antigen CD42b alpha antibody
- BSS antibody
- CD 42b antibody
see all
Database links
- Entrez Gene: 2811 Human
- Omim: 606672 Human
- SwissProt: P07359 Human
- Unigene: 1472 Human
References for Anti-CD42b antibody [VM16d] (ab34408)
This product has been referenced in:
- Mazurov AVet al. Characterization of an antiglycoprotein Ib monoclonal antibody that specifically inhibits platelet-thrombin interaction. Thromb Res 62:673-84 (1991).Read more (PubMed: 1718052) »
See 1 publication for this product
Publishing research using ab34408? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"