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Product name
Anti-CD45RC antibody [RP1/12] (Phycoerythrin)
See all CD45RC products (15) ...
Description
Mouse monoclonal [RP1/12] to CD45RC (Phycoerythrin)
Conjugation
Phycoerythrin
Specificity
ab90981 reacts with CD45RC on pre B lymphocytes, B cells, CD8+ T suppressor/cytotoxic cells and a subset of CD4+ T helper (Th) lymphocytes. It weakly reacts with thymocytes.
Tested applications
Flow Cytmore details
Cross reactivity
Reacts with
Human
Immunogen
PHA stimulated Human lymphocytes.
Properties
Form
Liquid
Storage instructions
Store at +4°C in the dark.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: 1% BSA, pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Monoclonal
Clone number
RP1/12
Isotype
IgG1
Research areas
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> T Lymphocytic Lineage
Stem Cells >> Hematopoietic Progenitors >> Lymphoid >> B Lymphocytic Lineage
Signal Transduction >> Protein Phosphorylation >> Tyrosine Phosphatases
Immunology >> Cell Type Markers >> CD >> Non-lineage
Immunology >> Adaptive Immunity >> T Cells >> CD
Immunology >> Adaptive Immunity >> B Cells >> CD
Applications
Show applications key
Our Abpromise guarantee covers the use of ab90981 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use 20µl for 106 cells.
Target
Relevance
The CD45 family of cell surface glycoprotein antigens exist as a set of isoforms. The patterns of monoclonal antibody recognition of the CD45 phenotypes can be restricted (CD45RA, RB and RC), or broader, such as the CD45 T 200 species. The "restricted" subsets of this group arise as a result of translation of alternatively spliced mRNAs from exons A, B and C (exons 4, 5 and 6), where exons 3-15 encode the extracellular domain of the CD45 molecule. The restricted epitopes are differentially expressed on T and B lymphocytes, including functionally distinct T cells. CD45 (LCA) is a transmembrane phosphotyrosine phosphatase expressed on leucocytes. Myeloid cells do not express the RC isoform.
Cellular localization
Membrane; Single-pass type I membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts.
Alternative names
- B220 antibody
- CD45 antibody
- CD45R antibody
see all
Database links
- Entrez Gene: 5788 Human
- Omim: 151460 Human
- SwissProt: P08575 Human
- Unigene: 654514 Human
References for Anti-CD45RC antibody [RP1/12] (Phycoerythrin) (ab90981)
ab90981 has not yet been referenced specifically in any publications.
Publishing research using ab90981? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"