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Product Name
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CD46 antibody [J4.48]
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See all CD46 antibodies (7)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [J4.48] to CD46
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Immunogen
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Tissue / cell preparation FKLY 18 B lymphoma cell line (Human).
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Reacts with
(species key)
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Hu
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Tested applications
(see key)
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Flow Cyt, ICC/IF
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use 2µg for 5x105 cells.
IF: Use 2µg for 5x105 cells.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Type I membrane protein.
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Research areas
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Immunology >> Innate Immunity >> Complement >> Regulatory
Immunology >> Cell Type Markers >> CD >> Non-lineage
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Relevance
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CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in the regulation of the complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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J4.48
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Myeloma
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NS1
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Isotype
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IgG1
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
Constituents: PBS, 1mg/ml BSA
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CD46 antibody [J4.48] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CD46
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CD46 antibody [J4.48] - more information
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Customer reviews (feedback) regarding CD46 antibody [J4.48] |
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