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Product Name
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CD46 antibody [MEM-258] (Allophycocyanin)
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See all CD46 antibodies (7)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [MEM-258] to CD46 (Allophycocyanin)
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Immunogen
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HPB-ALL human T cell line
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Reacts with
(species key)
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Hu, Cow
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Specificity
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ab60904 recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46.
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Tested applications
(see key)
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Flow Cyt
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use 10µl per 100µl of whole blood or 106 cells in suspension.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Human blood cells
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Cellular localization
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Type I membrane protein.
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Research areas
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Immunology >> Innate Immunity >> Complement >> Regulatory
Immunology >> Cell Type Markers >> CD >> Non-lineage
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Relevance
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CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in the regulation of the complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells.
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CD46 antibody [MEM-258] (Allophycocyanin) (ab60904) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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MEM-258
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Isotype
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IgG1
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Purity
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Size exclusion
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Storage buffer
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Preservative: 15mM Sodium Azide
Constituents: 0.2% high-grade protease free BSA, PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Purification notes
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Antibodies were purified by protein A (G) affinity chromatography before conjugation(purity: >95% by SDS-PAGE). The conjugated antibodies were purified by size exclusion chromatography.
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Form
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Liquid
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Conjugation
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Allophycocyanin
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Storage instructions
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Store at +4°C in the dark. Do not freeze.
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Notes
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Avoid prolonged exposure to light. Short-term exposure to room temperature should not affect the quality of the reagent.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CD46 antibody [MEM-258] (Allophycocyanin) is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CD46
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CD46 antibody [MEM-258] (Allophycocyanin) - more information
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