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Products:Immunology >> Cell Type Markers >> CD >> Adhesion
Overview
Product name
Anti-CD47 antibody [MEM-122]
See all CD47 products (7) ...
Description
Mouse monoclonal [MEM-122] to CD47
Specificity
Integrin Associated Protein
Tested applications
Flow Cyt, WB, IHC-Frmore details
Cross reactivity
Reacts with
Human, Pig, African Green Monkey
Predicted to work with
Non Human Primates
Immunogen
COS-7 (African green monkey) cells.
Properties
Form
Liquid
Storage instructions
Store at +4°C. Do not freeze.
Storage buffer
Preservative: 15mM Sodium Azide
Constituents: PBS, pH 7.4
Concentration
Concentration information loading...
Purity
>95% by SDS-PAGE
Purification notes
Purified from ascites by precipitation methods and size-exclusion chromatography.
Clonality
Monoclonal
Clone number
MEM-122
Isotype
IgM
Research areas
Cancer >> Tumor immunology >> CD markers
Immunology >> Cell Type Markers >> CD >> Adhesion
Applications
Show applications key
Our Abpromise guarantee covers the use of ab9089 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Flow Cyt: Use a concentration of 2 µg/ml
WB: Use at an assay dependent concentration. Use under non reducing condition.
IHC-Fr: Use at an assay dependent dilution.
Target
Function
Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.
Tissue specificity
Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.
Sequence similarities
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Cellular localization
Cell membrane.
Target information above from: UniProt accessionQ08722
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Antigenic surface determinant protein OA3 antibody
- CD 47 antibody
- CD47 antibody
see all
Database links
- Entrez Gene: 961 Human
- Entrez Gene: 397042 Pig
- Omim: 601028 Human
- SwissProt: Q08722 Human
- Unigene: 446414 Human
References for Anti-CD47 antibody [MEM-122] (ab9089)
ab9089 has not yet been referenced specifically in any publications.
Publishing research using ab9089? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"