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Product Name
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CD53 antibody [OX-80]
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See all CD53 antibodies (8)...
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Product type
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Primary antibodies
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Description
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Rat monoclonal [OX-80] to CD53
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Immunogen
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Tissue / cell preparation (Mouse): RAW264 cell line
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Reacts with
(species key)
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Ms
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Specificity
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ab22484 recognises CD53 cell surface antigen. It recognises an extracellular epitope and its binding is dependent upon the threonine residue at position 154.
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Tested applications
(see key)
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Flow Cyt
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use neat - 1/5. Use 10µl of the suggested working dilution for 106 cells.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Integral membrane protein.
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Research areas
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Signal Transduction >> Adapters >> Transmembrane
Immunology >> Cell Type Markers >> CD >> Non-lineage
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Relevance
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CD53 is a member of the tetraspan family of molecules, and is expressed by all leucocytes, but is absent from red cells and platelets.
Most of the tetraspan family of molecules are cell surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2 generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses.
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Database links
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The links below go to external sites and will open in a new browser window Entrez Gene | | 12508 (Mouse)
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Raised in
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Rat
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Clonality
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Monoclonal
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Clone number
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OX-80
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Isotype
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IgM
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Purity
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Tissue culture supernatant
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: Tissue culture supernatant Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CD53 antibody [OX-80] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CD53
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CD53 antibody [OX-80] - more information
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CD53 antibody [OX-80] - other tools:
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