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Product Name
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CD59 antibody [1B4]
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See all CD59 antibodies (17)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [1B4] to CD59
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Immunogen
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The details of the immunogen for this antibody are not available.
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Reacts with
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Rat
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Does not react with
(species key)
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Hu
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Tested applications
(see key)
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Flow Cyt, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use at a concentration of 10 µg/ml.
Use 10µl of the suggested working dilution to label 106 cells in 100µl.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Use under non reducing conditions. Predicted molecular weight: 14 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell membrane; Lipid-anchor, GPI-anchor. Secreted
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Research areas
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Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Innate and adaptive immunity
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
Immunology >> Innate Immunity >> Complement >> MAC
Immunology >> Cell Type Markers >> CD >> Non-lineage
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Relevance
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CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
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CD59 antibody [1B4] (ab33909) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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1B4
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Myeloma
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P3x63-Ag8.653
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Isotype
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IgG1
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Purity
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Protein A purified
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Storage buffer
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Preservative: 0.09% Sodium Azide
Constituents: PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CD59 antibody [1B4] is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CD59
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CD59 antibody [1B4] - more information
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Customer reviews (feedback) regarding CD59 antibody [1B4] |
Customer FAQs regarding CD59 antibody [1B4] |
Protocols for CD59 antibody [1B4] |
Price and availability of products related to CD59 antibody [1B4] |
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CD59 antibody [1B4] - other tools:
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Contact Abcam with a Technical Enquiry about CD59 antibody [1B4] |
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