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Product Name
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CD59 antibody [MEM-129] - Azide free
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See all CD59 antibodies (17)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [MEM-129] to CD59 - Azide free
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Immunogen
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Tissue / cell preparation (peripheral blood lymphocytes), (Human).
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Reacts with
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Hu
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Predicted to react
(species key)
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Pig
(Due to sequence homology)
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Specificity
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This antibody activates T cells.
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Tested applications
(see key)
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Flow Cyt
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use at an assay dependent dilution.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell membrane; Lipid-anchor, GPI-anchor. Secreted
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Research areas
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Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Innate and adaptive immunity
Stem Cells >> Hematopoietic Progenitors >> Surface Molecules
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
Immunology >> Innate Immunity >> Complement >> MAC
Immunology >> Cell Type Markers >> CD >> Non-lineage
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Relevance
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CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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MEM-129
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Isotype
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IgM
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Purity
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Purified IgM
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Storage buffer
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Preservative: None
Constituents: PBS, pH 7.4
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Store at +4°C. Do not freeze.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CD59 antibody [MEM-129] - Azide free is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to CD59
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