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Product Name
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CD62P antibody [C2] (Phycoerythrin)
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See all CD62P antibodies (15)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal [C2] to CD62P (Phycoerythrin)
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Immunogen
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The details of the immunogen for this antibody are not available. Please see reference below.
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Reacts with
(species key)
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Hu
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Specificity
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This antibody is specific for CD62P.
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Tested applications
(see key)
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Flow Cyt
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Flow Cyt: Use at an assay dependent dilution.
10µl is sufficient to label 100µl of staining volume.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Membrane; single pass type I membrane protein.
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Research areas
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Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Thrombocytic Lineage
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Cell adhesion molecules
Immunology >> Cell Type Markers >> CD >> Platelets
Cardiovascular >> Blood >> Platelets
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Relevance
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CD62P is a member of the small selectin family of cellular adhesion molecules, which also includes CD62E and CD62L. Its structure, similar to the other members of the selectin family, consists of an N terminal lectin like domain of C type, followed by an epidermal growth factor like motif, a series of short consensus repeats, a transmembrane domain, and a cytoplasmic tail. The CD62P antigen is a 140 kDa glycoprotein, located in the alpha granules and the dense granules of platelets and endothelial cells. Activation of these cells results in rapid mobilization of CD62P from the storage granules to the cell surface. Activated platelets have a stable CD62P expression, while the endothelial cells lose CD62P expression within 1 h of activation, because of endocytosis of the molecule. CD62P is also expressed on megakaryocytes, but resting platelets and endothelial cells show no surface staining of CD62P.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Clone number
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C2
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Isotype
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IgG1
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Purity
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Size exclusion
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: 0.5% BSA, PBS Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Conjugation
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Phycoerythrin
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this CD62P antibody [C2] (Phycoerythrin) is on this datasheet. But please do contact us if you would like any reassurance! |
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References for CD62P antibody [C2] (Phycoerythrin) (ab42795)
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This product has been used in:
Han JZ et al. Evoked intracellular Ca2+ elevations in HT4 neuroblastoma cells. Neuroreport 13:1089-94 (2002). PubMed: 12060815
If you publish research using ab42795 please let us know so that we can cite the reference on this datasheet.
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Search PubMed (MEDLINE) for references to CD62P
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CD62P antibody [C2] (Phycoerythrin) - more information
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