Anti-CD62P antibody [Psel.KO.2.12] (ab54426)
- Product nameAnti-CD62P antibody [Psel.KO.2.12]See all CD62P primary antibodies ...
- DescriptionMouse monoclonal [Psel.KO.2.12] to CD62P
- SpecificityThis antibody recognizes the CD62P cell surface antigen.
- Tested applicationsIP, IHC-Fr, Flow Cyt more details
- Species reactivityReacts with: Rat, Sheep, Goat, Human
CD62P transfected 300.19 cells (Human)
- General notesShelf Life - 18 months, product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
Clone Psel.KO.2.12 is reported to inhibit P selectin dependent adhesion between HL60 cells and P selectin transfected COS cells
- Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.09% Sodium Azide
Constituents: PBS, pH 7.4
- Concentration information loading...
- PurityProtein G purified
- Purification notesPurified from tissue culture supernatant
- Primary antibody notes Clone Psel.KO.2.12 is reported to inhibit P selectin dependent adhesion between HL60 cells and P selectin transfected COS cells
- Clonality Monoclonal
- Clone numberPsel.KO.2.12
- Research Areas
Our Abpromise guarantee covers the use of ab54426 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionCa(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
- Tissue specificityStored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
- Involvement in diseaseDefects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
- Sequence similaritiesBelongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 9 Sushi (CCP/SCR) domains.
- Cellular localizationMembrane.
- Antigen CD62 antibody
- CD62 antibody
- CD62 antigen-like family member P antibody
- CD62P antibody
- GMP 140 antibody
- GMP-140 antibody
- GMP140 antibody
- GMRP antibody
- Granule membrane protein 140 antibody
- Granulocyte membrane protein antibody
- GRMP antibody
- LECAM 3 antibody
- LECAM3 antibody
- Leukocyte endothelial cell adhesion molecule 3 antibody
- Leukocyte-endothelial cell adhesion molecule 3 antibody
- LYAM3_HUMAN antibody
- P Selectin antibody
- P-selectin antibody
- PADGEM antibody
- Platelet activation dependent granule-external membrane protein antibody
- Platelet alpha granule membrane protein antibody
- PSEL antibody
- Selectin P (granule membrane protein 140kDa, antigen CD62) antibody
- SELP antibody
References for Anti-CD62P antibody [Psel.KO.2.12] (ab54426)
ab54426 has not yet been referenced specifically in any publications.