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Products:Cardiovascular >> Blood >> Platelets
Overview
Product name
Anti-CD62P antibody
See all CD62P products (17) ...
Description
Rabbit polyclonal to CD62P
Specificity
The antibody recognizes 84kDa CD62P.
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide surrounding amino acid 756 of mouse CD62P.
Positive control
Jurkat cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 30% Glycerol, 0.5% BSA, PBS
Concentration
Concentration information loading...
Purification notes
affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Adaptive Immunity >> Regulatory T Cells
Stem Cells >> Hematopoietic Progenitors >> Myeloid >> Thrombocytic Lineage
Cardiovascular >> Atherosclerosis >> Vascular Inflammation >> Leukocyte recruitment >> Cell adhesion molecules
Immunology >> Cell Type Markers >> CD >> Platelets
Cardiovascular >> Blood >> Platelets
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Western blot - CD62P antibody (ab59738)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab59738 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 0.5 - 4 µg/ml.Detects a band of approximately 84 kDa (predicted molecular weight: 91 kDa).
Target
Function
Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
Tissue specificity
Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
Involvement in disease
Defects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Sequence similarities
Belongs to the selectin/LECAM family.
Contains 1 C-type lectin domain.
Contains 1 EGF-like domain.
Contains 9 Sushi (CCP/SCR) domains.
Cellular localization
Membrane.
Target information above from: UniProt accessionP16109
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Antigen CD62 antibody
- CD62 antibody
- CD62 antigen-like family member P antibody
see all
Database links
- Entrez Gene: 6403 Human
- Entrez Gene: 20344 Mouse
- Entrez Gene: 25651 Rat
- Omim: 173610 Human
- SwissProt: P16109 Human
- SwissProt: Q01102 Mouse
- SwissProt: P98106 Rat
- Unigene: 73800 Human
see all
Anti-CD62P antibody images:
Western blot - CD62P antibody (ab59738)
Anti-CD62P antibody (ab59738) at 0.5 µg/ml + Jurkat cell lysate
Predicted band size : 91 kDa
Observed band size : 84 kDa (why is the actual band size different from the predicted?)
References for Anti-CD62P antibody (ab59738)
This product has been referenced in:
- He Met al. Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis. Am J Physiol Gastrointest Liver Physiol 292:G1173-80 (2007).Read more (PubMed: 17234893) »
- Lau HY & Bhatia M Effect of CP-96,345 on the expression of adhesion molecules in acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol 292:G1283-92 (2007).Read more (PubMed: 17218475) »
See all 2 publications for this product
Publishing research using ab59738? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"