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Overview

  • Product nameCD62P proteinSee all CD62P proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to the signal peptide and the extracellular amino acids 1-771 of Human CD62P, expressed in modified human 293 cells, 85kDa. Swiss ID P16109.
  • Expression hostHEK 293 cells

    • Properties

  • Purity> 95 % by SDS-PAGE
  • FormLyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.
  • Storage instructionsShipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 10% Trehalose, 1% Human serum albumin, PBS
  • Concentration information loading...
  • Sequence notesTheoretical sequence: MANCQIAILYQRFQRVVFGISQLLCFSAL ISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRY TDL VAIQNKNEIDYLNKVLPYYSSYYWIGIRKNNKTWTWVGTK KALTNEAENWADNEPNNKRN NEDCVEIYIKSPSAPGKW NDEHCLKKKHALCYTASCQDMSCSKQGECLETIGNYTCSC YPGF YGPECEYVRECGELELPQHVLMNCSHPLGNFSFN SQCSFHCTDGYQVNGPSKLECLASGIW TNKPPQCLAAQ CPPLKIPERGNMTCLHSAKAFQHQSSCSFSCEEGFALVGP EVVQCTASGV WTAPAPVCKAVQCQHLEAPNEGTMDCVH PLTAFAYGSSCKFECQPGYRVRGLDMLRCIDSG HWSAP LPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTNCSFRCA EGFMLRGADIVRCDNLG QWTAPAPVCQALQCQDLPVPN EARVNCSHPFGAFRYQSVCSFTCNEGLLLVGASVLQCLAT GNWNSVPPECQAIPCTPLLSPQNGTMTCVQPLGSSSYK STCQFICDEGYSLSGPERLDCTRS GRWTDSPPMCEAIK CPELFAPEQGSLDCSDTRGEFNVGSTCHFSCNNGFKLEGP NNVECTT SGRWSATPPTCKGIASLPTPGVQCPALTTPG QGTMYCRHHPGTFGFNTTCYFGCNAGFTLIG DSTLSCR PSGQWTAVTPACRAVKCSELHVNKPIAMNCSNLWGNFSYG SICSFHCLEGQLLNG SAQTACQENGHWSTTVPTCQAGP LTIQEA
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab83582 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution. Protein migrates as a broad band between 100 and 140 kDa due to post-translational modifications, in particular glycosylaton.

    Protein info

    • Alternative names
        Antigen CD62CD62CD62 antigen-like family member P
        CD62PGMP 140GMP-140GMRPGranule membrane protein 140Granulocyte membrane proteinGRMPLECAM 3LECAM3Leukocyte endothelial cell adhesion molecule 3Leukocyte-endothelial cell adhesion molecule 3LYAM3_HUMANP SelectinP-selectinPADGEMPlatelet activation dependent granule-external membrane proteinPSELSELP
      see all
  • FunctionCa(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
  • Tissue specificityStored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
  • Involvement in diseaseDefects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
  • Sequence similaritiesBelongs to the selectin/LECAM family.
    Contains 1 C-type lectin domain.
    Contains 1 EGF-like domain.
    Contains 9 Sushi (CCP/SCR) domains.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession P16109 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    CD62P protein images

    • SDS-PAGE - CD62P protein (ab83582)
      SDS-PAGE - CD62P protein (ab83582)
      Lane 1 ab83582; Lane 2 ab83582 treated with PNGase F to remove potential Nlinked glycans; Lane 3 ab83582 treated with a glycosidase cocktail to remove potential N- and O-linked glycans. 10 µg protein loaded per lane; Deep Purple™ stained.

      Drop in MW after treatment with PNGase F indicates presence of N-linked glycans. A further drop in MW after treatment with the glycosidase cocktail indicates the presence of O linked glycans. Additional bands in lane 2 and lane 3 are glycosidase enzymes.

    References for CD62P protein (ab83582)

    ab83582 has not yet been referenced specifically in any publications.

    Publishing research using ab83582 ? Please let us know so that we can cite the reference in this datasheet

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