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Products:Cardiovascular >> Blood >> Platelets
Overview
Product name
Anti-CD63 antibody [CLB-180]
See all CD63 products (22) ...
Description
Mouse monoclonal [CLB-180] to CD63
Tested applications
IF, Flow Cytmore details
Cross reactivity
Reacts with
Human
Immunogen
Tissue / cell preparation. Cytochrome-B enriched cells (Human).
Properties
Form
Liquid
Storage instructions
Store at +4°C in the dark.
Storage buffer
Preservative: 0.001% Thimerosal (merthiolate)
Constituents: 10mg/ml BSA, 20mM Tris HCl, 150mM Sodium chloride, pH 8
Concentration
Concentration information loading...
Purification notes
Purification through affinity chromatography.
Primary antibody notes
ab23792 can be used for detection of activated platelets and thrombus imaging.
Clonality
Monoclonal
Clone number
CLB-180
Isotype
IgG1
Research areas
Cancer >> Tumor biomarkers >> Tumor antigens
Cancer >> Invasion/microenvironment >> ECM >> Cell adhesion >> Other
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Immunology >> Cell Type Markers >> CD >> Platelets
Cardiovascular >> Blood >> Platelets
Applications
Show applications key
Our Abpromise guarantee covers the use of ab23792 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IF: Use at an assay dependent dilution.
Flow Cyt: Use at an assay dependent dilution.
Target
Function
This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.
Tissue specificity
Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Sequence similarities
Belongs to the tetraspanin (TM4SF) family.
Cellular localization
Cell membrane. Lysosome membrane. Late endosome membrane. Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules.
Target information above from: UniProt accessionP08962
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Lysosomal associated membrane protein 3 antibody
- CD 63 antibody
- CD63 antibody
see all
Database links
- Entrez Gene: 967 Human
- Omim: 155740 Human
- SwissProt: P08962 Human
- Unigene: 445570 Human
References for Anti-CD63 antibody [CLB-180] (ab23792)
This product has been referenced in:
- Pivot-Pajot Cet al. Characterisation of degranulation and phagocytic capacity of a human neutrophilic cellular model, PLB-985 cells. Immunobiology 215:38-52 (2010). Flow Cyt; Human.Read more (PubMed: 19250699) »
- Groppelli Eet al. Cell entry of the aphthovirus equine rhinitis A virus is dependent on endosome acidification. J Virol 84:6235-40 (2010).Read more (PubMed: 20375159) »
See all 2 publications for this product
Publishing research using ab23792? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"