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Products:Cardiovascular >> Blood >> Platelets

Anti-CD63 antibody [NK1/C3] (ab1318)

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Overview

Product name

Anti-CD63 antibody [NK1/C3]
See all CD63 products (22) ...

Description

Mouse monoclonal [NK1/C3] to CD63

Specificity

This antibody is specific to a 53 kD protein, expressed on activated platelets. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. It is also expressed on granulocytes, B cells and T cells.

Tested applications

ICC, IHC-P, IHC-Fr, Flow Cytmore details

Cross reactivity

Reacts with

Human

Immunogen

Smooth plasma membrane fraction of MeWo cells.

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 1% BSA

Concentration

Concentration information loading...

Purity

IgG fraction

Primary antibody notes

CD63 is expressed on activated platelets. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. It is also present in monocytes and macrophages and is weakly expressed in granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen ME491 and to the platelet antigen PTLGP40.

Clonality

Monoclonal

Clone number

NK1/C3

Isotype

IgG1

Light chain type

kappa

Research areas

Cancer >> Tumor biomarkers >> Tumor antigens
Cancer >> Invasion/microenvironment >> ECM >> Cell adhesion >> Other
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated
Immunology >> Cell Type Markers >> CD >> Platelets
Cardiovascular >> Blood >> Platelets

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD63 antibody [NK1/C3] (ab1318)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD63 antibody [NK1/C3] (ab1318) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab1318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.

Tissue specificity

Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.

Sequence similarities

Belongs to the tetraspanin (TM4SF) family.

Cellular localization

Cell membrane. Lysosome membrane. Late endosome membrane. Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules.

Target information above from: UniProt accessionP08962 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Lysosomal associated membrane protein 3 antibody
  • CD 63 antibody
  • CD63 antibody
  • CD63 antigen antibody
  • CD63 antigen melanoma 1 antigen antibody
  • CD63 molecule antibody
  • CD63_HUMAN antibody
  • gp55 antibody
  • granulophysin antibody
  • LAMP 3 antibody
  • LAMP-3 antibody
  • LAMP3 antibody
  • LIMP antibody
  • Lysosomal-associated membrane protein 3 antibody
  • lysosome associated membrane glycoprotein 3 antibody
  • Mast cell antigen AD1 antibody
  • ME491 antibody
  • melanoma 1 antigen antibody
  • Melanoma associated antigen ME491 antibody
  • Melanoma associated antigen MLA1 antibody
  • Melanoma-associated antigen ME491 antibody
  • MGC72893 antibody
  • MLA 1 antibody
  • MLA1 antibody
  • NGA antibody
  • ocular melanoma associated antigen antibody
  • Ocular melanoma-associated antigen antibody
  • OMA81H antibody
  • PTLGP40 antibody
  • Tetraspanin 30 antibody
  • Tetraspanin-30 antibody
  • Tspan 30 antibody
  • Tspan-30 antibody
  • TSPAN30 antibody
see all

Database links

Anti-CD63 antibody [NK1/C3] images:

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD63 antibody [NK1/C3] (ab1318)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - CD63 antibody [NK1/C3] (ab1318)

ab1318 staining human melanoma by IHC-P.

References for Anti-CD63 antibody [NK1/C3] (ab1318)

This product has been referenced in:

  • Turner NAet al. Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. Blood 114:5102-11 (2009). ICC/IF; Human.Read more (PubMed: 19822897) »
  • Wang ALet al. Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration. PLoS One 4:e4160 (2009). IHC-P, Flow Cyt; Human.Read more (PubMed: 19129916) »

See all 8 publications for this product

Publishing research using ab1318? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"