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Anti-CD66a + CD66c + CD66d + CD66e antibody [CLB-gran/10, IH4Fc] (ab51670)

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Overview

Product name

Anti-CD66a + CD66c + CD66d + CD66e antibody [CLB-gran/10, IH4Fc]
See all CD66a + CD66c + CD66d + CD66e products (5) ...

Description

Mouse monoclonal [CLB-gran/10, IH4Fc] to CD66a + CD66c + CD66d + CD66e

Specificity

The monoclonal antibody is directed against the CD66acde antigen. The monoclonal antibody reacts with 100% of mature human peripheral granulocytes. It reacts weak with malignant cells of patients with B cell derived Chronic Lymphoid Leukaemia (CLL). The monoclonal antibody does not react with normal human peripheral B cells, T cells, monocytes and platelets. In immunohistology the monoclonal antibody reacts with some tissue macrophages and CEA, the Carcino Embryonic Antigen, expressed on colon carcinoma and other carcinomas.

Tested applications

Flow Cytmore details

Cross reactivity

Reacts with

Human

Immunogen

Human granulocytes

Properties

Form

Liquid

Storage instructions

Store at +4°C in the dark.

Storage buffer

Preservative: 0.001% Thimerosal (merthiolate)
Constituents: 10 mg BSA, 20mM Tris, 150mM Sodium chloride, pH 8

Purity

Tissue culture supernatant

Purification notes

Affinity chromatography.

Clonality

Monoclonal

Clone number

CLB-gran/10, IH4Fc

Myeloma

Sp2/0

Isotype

IgG1

Research areas

Cancer >> Tumor biomarkers >> Tumor antigens
Cancer >> Tumor immunology >> Tumor-associated antigens
Tags & Cell Markers >> Cell Type Markers >> Tumor Associated

Applications

Show applications key

Our Abpromise guarantee covers the use of ab51670 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Flow Cyt

     

Application notes

Flow Cyt: Use at an assay dependent dilution.
Study of mature granulocytes in peripheral blood.
Indirect immunofluorescence staining with analysis by flow cytometry or
fluorescence microscopy.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

CD66a, CD66c, CD66d and CD66e are four members of the carcinoembryonic antigen family and are expressed on human neutrophils. In neutrophils these proteins are activation antigens in that their surface expression is increased following stimulation.

Cellular localization

Cell membrane; lipid anchor; GPI anchor

Alternative names

  • Antigen CD66 antibody
  • Biliary glycoprotein antibody
  • Carcinoembryonic antigen antibody
  • Carcinoembryonic antigen related cell adhesion molecule 1 antibody
  • Carcinoembryonic antigen related cell adhesion molecule 3 antibody
  • Carcinoembryonic antigen related cell adhesion molecule 5 antibody
  • Carcinoembryonic antigen related cell adhesion molecule 6 antibody
  • CD66a antigen antibody
  • CD66d antibody
  • CD66e antibody
  • CD66e antigen antibody
  • CEACAM1 antibody
  • CEACAM3 antibody
  • CEACAM5 antibody
  • CEACAM6 antibody
see all

Database links

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References for Anti-CD66a + CD66c + CD66d + CD66e antibody [CLB-gran/10, IH4Fc] (ab51670)

ab51670 has not yet been referenced specifically in any publications.

Publishing research using ab51670? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"