You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Reassurance, Refunds & Replacements

If your product does not perform as described on this datasheet, we will refund or replace your product...

Read our guarantee »
 

Anti-CD68 antibody [PG-M1] (ab783)

CodeSizePriceAbpointsAvailability
    
Add to basket
 
  • -
  •   
  •   
  •   
  •  
  •   
  •   
Updating...

Overview

Product name

Anti-CD68 antibody [PG-M1]
See all CD68 products (17) ...

Description

Mouse monoclonal [PG-M1] to CD68

Specificity

This antibody reacts with a glycoprotein of 110 kDa, expressed as an intracytoplasmic molecule. It stains macrophages in a wide variety of tissues. Myeloid precursor cells and peripheral granulocytes are negative.

Tested applications

IHC-Pmore details

Cross reactivity

Reacts with

Human

Immunogen

Gaucher cells

Positive control

tonsil

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 1% BSA, Tissue culture supernatant

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

PG-M1

Isotype

IgG3

Light chain type

kappa

Research areas

Immunology >> Cell Type Markers >> CD >> Myeloid Cells

Applications

Show applications key

Our Abpromise guarantee covers the use of ab783 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide1 Image

    IHC-P

    Five stars (1 Abreview) IHC-P: 1/10 - 1/40.Perfo...Read more →

    IHC-P: 1/10 - 1/40.Perform enzymatic antigen retrieval before commencing with IHC staining protocol.((use ABC method). We suggest an incubation period of 30-60 minutes at room temperature.)

Application notes

Is unsuitable for ,ICC or IHC-Fr.

Target

Function

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

Tissue specificity

Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

Sequence similarities

Belongs to the LAMP family.

Post-translational
modifications

N- and O-glycosylated.

Cellular localization

Cell membrane and Endosome membrane. Lysosome membrane.

Target information above from: UniProt accessionP34810 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CD 68 antibody
  • CD68 antibody
  • CD68 antigen antibody
  • CD68 molecule antibody
  • CD68_HUMAN antibody
  • DKFZp686M18236 antibody
  • GP110 antibody
  • Macrophage antigen CD68 (microsialin) antibody
  • macrosialin antibody
  • SCARD1 antibody
  • Scavenger receptor class D member 1 antibody
see all

Database links

References for Anti-CD68 antibody [PG-M1] (ab783)

This product has been referenced in:

  • Horny HPet al. Immunoreactivity of normal and neoplastic human tissue mast cells with macrophage-associated antibodies, with special reference to the recently developed monoclonal antibody PG-M1. Hum Pathol 24:355-8 (1993).Read more (PubMed: 8491475) »
  • Kaiserling Eet al. Aberrant expression of macrophage-associated antigens (CD68 and Ki-M1P) by Schwann cells in reactive and neoplastic neural tissue. Light- and electron-microscopic findings. Mod Pathol 6:463-8 (1993).Read more (PubMed: 8415593) »

See all 3 publications for this product

Publishing research using ab783? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"