Overview

  • Product name
    Anti-CD70 antibody [TAN 1-7]
    See all CD70 primary antibodies
  • Description
    Rat monoclonal [TAN 1-7] to CD70
  • Specificity
    This antibody is a non-depleting mAb that blocks the CD70-CD27 interaction.
  • Tested applications
    Suitable for: ELISA, Flow Cyt, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant mouse CD70 (extracellular domain, aa residues 41-195).

  • Positive control
    • Activated dendritic cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab108482 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab18450-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
ICC/IF Use at an assay dependent concentration.

Target

  • Function
    Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
  • Sequence similarities
    Belongs to the tumor necrosis factor family.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 27L antibody
    • CD 70 antibody
    • CD27 L antibody
    • CD27 LG antibody
    • CD27 ligand antibody
    • CD27-L antibody
    • CD27L antibody
    • CD27LG antibody
    • CD70 antibody
    • CD70 antigen antibody
    • CD70 molecule antibody
    • CD70_HUMAN antibody
    • Ki 24 antigen antibody
    • Ki24 antigen antibody
    • Surface antigen CD70 antibody
    • TNFSF 7 antibody
    • TNFSF7 antibody
    • Tumor necrosis factor (ligand) superfamily, member 7 antibody
    • Tumor necrosis factor ligand superfamily member 7 antibody
    see all

References

This product has been referenced in:
  • Taraban VY  et al. Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells. J Immunol 180:4615-20 (2008). Read more (PubMed: 18354184) »
  • Rowley TF & Al-Shamkhani A Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo. J Immunol 172:6039-46 (2004). Read more (PubMed: 15128787) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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