Anti-CD70 antibody [TAN 1-7] (ab108482)
Overview
- Product nameAnti-CD70 antibody [TAN 1-7]See all CD70 primary antibodies ...
- DescriptionRat monoclonal [TAN 1-7] to CD70
- SpecificityThis antibody is a non-depleting mAb that blocks the CD70-CD27 interaction.
- Tested applicationsELISA, Flow Cyt, ICC/IF more details
- Species reactivityReacts with: Mouse
- Immunogen
Recombinant mouse CD70 (extracellular domain, aa residues 41-195).
- Positive controlActivated dendritic cells.
Properties
- FormLiquid
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
Constituents: PBS -
Concentration information loading... - PurityIgG fraction
- Clonality Monoclonal
- Clone numberTAN 1-7
- MyelomaNS0
- IsotypeIgG2a
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab108482 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| ELISA | ELISA: Use at an assay dependent dilution. |
| Flow Cyt | Flow Cyt: Use at an assay dependent dilution. |
| ICC/IF | ICC/IF: Use at an assay dependent dilution. |
Target
- FunctionCytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
- Sequence similaritiesBelongs to the tumor necrosis factor family.
- Cellular localizationMembrane.
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Database links
- Entrez Gene: 21948 Mouse
- SwissProt: O55237 Mouse
- Unigene: 42228 Mouse
Target information above from: UniProt accession
P32970
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- CD 27L antibodyCD 70 antibodyCD27 L antibody
- CD27 LG antibodyCD27 ligand antibodyCD27-L antibodyCD27L antibodyCD27LG antibodyCD70 antibodyCD70 antigen antibodyCD70 molecule antibodyCD70_HUMAN antibodyKi 24 antigen antibodyKi24 antigen antibodySurface antigen CD70 antibodyTNFSF 7 antibodyTNFSF7 antibodyTumor necrosis factor ligand superfamily member 7 antibody
see all
References for Anti-CD70 antibody [TAN 1-7] (ab108482)
This product has been referenced in:
- Taraban VY et al. Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells. J Immunol 180:4615-20 (2008). Read more (PubMed: 18354184) »
- Rowley TF & Al-Shamkhani A Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo. J Immunol 172:6039-46 (2004). Read more (PubMed: 15128787) »
