Overview

  • Product nameAnti-CD70 antibody [TAN 1-7]See all CD70 primary antibodies ...
  • Description
    Rat monoclonal [TAN 1-7] to CD70
  • SpecificityThis antibody is a non-depleting mAb that blocks the CD70-CD27 interaction.
  • Tested applicationsELISA, Flow Cyt, ICC/IF more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant mouse CD70 (extracellular domain, aa residues 41-195).

  • Positive control
    • Activated dendritic cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab108482 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA Use at an assay dependent dilution.
Flow Cyt Use at an assay dependent dilution.
ICC/IF Use at an assay dependent dilution.

Target

  • FunctionCytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.
  • Sequence similaritiesBelongs to the tumor necrosis factor family.
  • Cellular localizationMembrane.
  • Target information above from: UniProt accession P32970 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • CD 27L antibody
    • CD 70 antibody
    • CD27 L antibody
    • CD27 LG antibody
    • CD27 ligand antibody
    • CD27-L antibody
    • CD27L antibody
    • CD27LG antibody
    • CD70 antibody
    • CD70 antigen antibody
    • CD70 molecule antibody
    • CD70_HUMAN antibody
    • Ki 24 antigen antibody
    • Ki24 antigen antibody
    • Surface antigen CD70 antibody
    • TNFSF 7 antibody
    • TNFSF7 antibody
    • Tumor necrosis factor (ligand) superfamily, member 7 antibody
    • Tumor necrosis factor ligand superfamily member 7 antibody
    see all

References for Anti-CD70 antibody [TAN 1-7] (ab108482)

This product has been referenced in:
  • Taraban VY  et al. Invariant NKT cells promote CD8+ cytotoxic T cell responses by inducing CD70 expression on dendritic cells. J Immunol 180:4615-20 (2008). Read more (PubMed: 18354184) »
  • Rowley TF & Al-Shamkhani A Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo. J Immunol 172:6039-46 (2004). Read more (PubMed: 15128787) »

See all 2 Publications for this product

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