Overview

  • Product nameAnti-CD74 antibody [OX 6] (FITC)See all CD74 primary antibodies ...
  • Description
    Mouse monoclonal [OX 6] to CD74 (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Tested applicationsIHC-P, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • General notes


    ab21419 detects Ia antigens from rat strains Wistar, PVG, Sprague Dawley, Lewis and AO. Other strains have not been tested. The antibody labels B lymphocytes, various epithelial cells, dendritic cells and macrophages. T lymphocytes are not labelled with this antibody. ab21419 detects Ia specificity 17 from the mouse H-2 haplotypes f,k,r,s and u but not with b,d,p,q or v haplotypes. ab21419 can be used for the purification of Ia antigen from rat spleen.

Properties

  • FormLiquid
  • Storage instructionsStore at +4°C.
  • Storage bufferPreservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • PurityIgG fraction
  • Primary antibody notes ab21419 detects Ia antigens from rat strains Wistar, PVG, Sprague Dawley, Lewis and AO. Other strains have not been tested. The antibody labels B lymphocytes, various epithelial cells, dendritic cells and macrophages. T lymphocytes are not labelled with this antibody. ab21419 detects Ia specificity 17 from the mouse H-2 haplotypes f,k,r,s and u but not with b,d,p,q or v haplotypes. ab21419 can be used for the purification of Ia antigen from rat spleen.
  • Clonality Monoclonal
  • Clone numberOX 6
  • IsotypeIgG1
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab21419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
Flow Cyt
  • Application notesFlow Cyt: 1/5 - 1/25.
    IHC-P (periodate lysine paraformaldehyde fixed) : 1/5 - 1/25.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
    • Sequence similaritiesContains 1 thyroglobulin type-1 domain.
    • Cellular localizationCell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD 74 antibody
      • CD74 antibody
      • CD74 antigen antibody
      • CD74 molecule antibody
      • CLIP antibody
      • DHLAG antibody
      • Gamma chain of class II antigens antibody
      • HG2A_HUMAN antibody
      • HLA class II histocompatibility antigen gamma chain antibody
      • HLA DR antigens associated invariant chain antibody
      • HLA DR gamma antibody
      • HLA-DR antigens-associated invariant chain antibody
      • HLA-DR-gamma antibody
      • HLADG antibody
      • HLADR antigens associated invariant chain antibody
      • Ia antigen associated invariant chain antibody
      • Ia antigen-associated invariant chain antibody
      • Ia associated invariant chain antibody
      • Ia gamma antibody
      • Ii antibody
      • Invariant polypeptide of major histocompatibility complex class II antigen associated antibody
      • la-gamma antibody
      • Major histocompatibility complex class II invariant chain antibody
      • MHC HLA DR gamma chain antibody
      • MHC HLA-DR gamma chain antibody
      • p33 antibody
      • p35 antibody
      • Probable protein disulfide isomerase ER60 precursor antibody
      • Protein 41 antibody
      see all

    Anti-CD74 antibody [OX 6] (FITC) images

    • ab21419 staining MHC Class II Ia in rat spleen cells by Flow Cytometry analysis.

    References for Anti-CD74 antibody [OX 6] (FITC) (ab21419)

    This product has been referenced in:
    • Gregori S  et al. A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes. J Immunol 162:6630-40 (1999). Read more (PubMed: 10352280) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab21419.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"