Overview

  • Product name
    Anti-CD74 antibody [OX 6] (FITC)
    See all CD74 primary antibodies
  • Description
    Mouse monoclonal [OX 6] to CD74 (FITC)
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Tested applications
    Suitable for: IHC-P, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • General notes


    ab21419 detects Ia antigens from rat strains Wistar, PVG, Sprague Dawley, Lewis and AO. Other strains have not been tested. The antibody labels B lymphocytes, various epithelial cells, dendritic cells and macrophages. T lymphocytes are not labelled with this antibody. ab21419 detects Ia specificity 17 from the mouse H-2 haplotypes f,k,r,s and u but not with b,d,p,q or v haplotypes. ab21419 can be used for the purification of Ia antigen from rat spleen.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: 0.01% Sodium Azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity
    IgG fraction
  • Primary antibody notes
    ab21419 detects Ia antigens from rat strains Wistar, PVG, Sprague Dawley, Lewis and AO. Other strains have not been tested. The antibody labels B lymphocytes, various epithelial cells, dendritic cells and macrophages. T lymphocytes are not labelled with this antibody. ab21419 detects Ia specificity 17 from the mouse H-2 haplotypes f,k,r,s and u but not with b,d,p,q or v haplotypes. ab21419 can be used for the purification of Ia antigen from rat spleen.
  • Clonality
    Monoclonal
  • Clone number
    OX 6
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab21419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/5 - 1/25.

Periodate lysine paraformaldehyde fixed.

Flow Cyt 1/5 - 1/25. ab91356-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
  • Sequence similarities
    Contains 1 thyroglobulin type-1 domain.
  • Cellular localization
    Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 74 antibody
    • CD74 antibody
    • CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody
    • CD74 antigen antibody
    • CD74 molecule antibody
    • CD74 molecule, major histocompatibility complex, class II invariant chain antibody
    • CLIP antibody
    • DHLAG antibody
    • Gamma chain of class II antigens antibody
    • HG2A_HUMAN antibody
    • HLA class II histocompatibility antigen gamma chain antibody
    • HLA DR antigens associated invariant chain antibody
    • HLA DR gamma antibody
    • HLA-DR antigens-associated invariant chain antibody
    • HLA-DR-gamma antibody
    • HLADG antibody
    • HLADR antigens associated invariant chain antibody
    • Ia antigen associated invariant chain antibody
    • Ia antigen-associated invariant chain antibody
    • Ia associated invariant chain antibody
    • Ia gamma antibody
    • Ii antibody
    • Invariant polypeptide of major histocompatibility complex class II antigen associated antibody
    • la-gamma antibody
    • Major histocompatibility complex class II invariant chain antibody
    • MHC HLA DR gamma chain antibody
    • MHC HLA-DR gamma chain antibody
    • p33 antibody
    • p35 antibody
    • Protein 41 antibody
    see all

Images

  • ab21419 staining MHC Class II Ia in rat spleen cells by Flow Cytometry analysis.

References

This product has been referenced in:
  • Gregori S  et al. A peptide binding motif for I-Eg7, the MHC class II molecule that protects E alpha-transgenic nonobese diabetic mice from autoimmune diabetes. J Immunol 162:6630-40 (1999). Read more (PubMed: 10352280) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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