Anti-CD74 antibody [OX 6] (FITC) (ab21419)

Overview

• Product nameAnti-CD74 antibody [OX 6] (FITC)See all CD74 primary antibodies ...
• Description
  Mouse monoclonal [OX 6] to CD74 (FITC)
• ConjugationFITC
• Tested applicationsIHC-P, Flow Cyt more details
• Species reactivity
  Reacts with: Mouse, Rat
  
• Immunogen

  The details of the immunogen for this antibody are not available.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.01% Sodium Azide
  Constituents: 50% Glycerol, PBS
• Concentration information loading...
• PurityIgG fraction
• Primary antibody notes ab21419 detects Ia antigens from rat strains Wistar, PVG, Sprague Dawley, Lewis and AO. Other strains have not been tested. The antibody labels B lymphocytes, various epithelial cells, dendritic cells and macrophages. T lymphocytes are not labelled with this antibody. ab21419 detects Ia specificity 17 from the mouse H-2 haplotypes f,k,r,s and u but not with b,d,p,q or v haplotypes. ab21419 can be used for the purification of Ia antigen from rat spleen.
• Clonality Monoclonal
• Clone numberOX 6
• IsotypeIgG1
• Research Areas
  • Immunology
  • Adaptive Immunity
  • MHC
  • Class II

  • Immunology
  • Adaptive Immunity
  • B Cells
  • CD

Applications

Target

• FunctionPlays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.
• Sequence similaritiesContains 1 thyroglobulin type-1 domain.
• Cellular localizationCell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.

Target information above from: UniProt accession P04233 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 16149 Mouse
  • Entrez Gene: 25599 Rat
  • SwissProt: P04441 Mouse
  • SwissProt: P10247 Rat
  • Unigene: 33804 Rat

• Alternative names
  CD 74 antibodyCD74 antibodyCD74 antigen antibody

  CD74 molecule antibodyCLIP antibodyDHLAG antibodyGamma chain of class II antigens antibodyHG2A_HUMAN antibodyHLA class II histocompatibility antigen gamma chain antibodyHLA DR antigens associated invariant chain antibodyHLA DR gamma antibodyHLA-DR antigens-associated invariant chain antibodyHLA-DR-gamma antibodyHLADG antibodyHLADR antigens associated invariant chain antibodyIa antigen associated invariant chain antibodyIa antigen-associated invariant chain antibodyIa associated invariant chain antibodyIa gamma antibodyIi antibodyInvariant polypeptide of major histocompatibility complex class II antigen associated antibodyla-gamma antibodyMajor histocompatibility complex class II invariant chain antibodyMHC HLA DR gamma chain antibodyMHC HLA-DR gamma chain antibodyp33 antibodyp35 antibodyProbable protein disulfide isomerase ER60 precursor antibodyProtein 41 antibody

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Anti-CD74 antibody [OX 6] (FITC) images

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  Flow Cytometry - CD74 antibody [OX 6] (FITC) (ab21419)
  ab21419 staining MHC Class II Ia in rat spleen cells by Flow Cytometry analysis.