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Anti-CD8 alpha antibody [3-298] (Biotin) (ab25167)

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Overview

  • Product nameAnti-CD8 alpha antibody [3-298] (Biotin)See all CD8 alpha primary antibodies ...
  • Description
    Mouse monoclonal [3-298] to CD8 alpha (Biotin)
  • ConjugationBiotin
  • Tested applicationsFlow Cyt, IP, IHC-Fr more details
  • Species reactivity
    Reacts with: Chicken, Turkey
  • Immunogen

    The details of the immunogen for this antibody are not available.

Properties

Applications

Our Abpromise guarantee covers the use of ab25167 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt
IP
IHC-Fr
  • Application notesFlow Cyt: Use 1µg for 106 cells.
    IHC-Fr: Use with acetone fixed tissues, at an assay dependent dilution.
    IP: Use at an assay dependent dilution.
    Purification of CD8+ T cells by positive cell sorting: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionIdentifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
    • Involvement in diseaseDefects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
    • Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Post-translational
      modifications      All of the five most carboxyl-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
    • Cellular localizationSecreted and Cell membrane.

      • Target information above from: UniProt accession P01732 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Alternative names
        CD 8a antibodyCD8 alpha chain antibodyCD8 antibody
        CD8 antigen alpha chain antibodyCD8 antigen alpha polypeptide antibodyCD8 antigen alpha polypeptide (p32) antibodyCD8a antibodyCD8a antigen antibodyCD8a molecule antibodyCD8A_HUMAN antibodyLeu 2 antibodyLeu2 antibodyLeu2 T lymphocyte antigen antibodyMAL antibodyOKT8 T cell antigen antibodyOTTHUMP00000160760 antibodyOTTHUMP00000160764 antibodyOTTHUMP00000203528 antibodyOTTHUMP00000203721 antibodyp32 antibodyT cell antigen Leu2 antibodyT cell co receptor antibodyT cell coreceptor antibodyT cell surface glycoprotein CD8 alpha chain antibodyT lymphocyte differentiation antigen T8/Leu 2 antibodyT lymphocyte differentiation antigen T8/Leu2 antibodyT-cell surface glycoprotein CD8 alpha chain antibodyT-lymphocyte differentiation antigen T8/Leu-2 antibodyT8 T cell antigen antibody
      see all

    References for Anti-CD8 alpha antibody [3-298] (Biotin) (ab25167)

    ab25167 has not yet been referenced specifically in any publications.

    Publishing research using ab25167 ? Please let us know so that we can cite the reference in this datasheet

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