Anti-CD8 antibody [YTC 182.20] (FITC) (ab34153)

Overview

• Product nameAnti-CD8 antibody [YTC 182.20] (FITC)See all CD8 primary antibodies ...
• Description
  Rat monoclonal [YTC 182.20] to CD8 (FITC)
• ConjugationFITC
• Tested applicationsFlow Cyt more details
• Species reactivity
  Reacts with: Human, Monkey, Cynomolgus Monkey, Rhesus monkey
  
• Immunogen

  Mouse L cells transfected with human CD8 gene.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Store in the dark. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 1% BSA, PBS, pH 7.2
• Concentration information loading...
• PurityProtein A purified
• Clonality Monoclonal
• Clone numberYTC 182.20
• MyelomaY3/Ag1.2.3
• IsotypeIgG2b
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • T Lymphocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Dendritic Cell Lineage

  • Immunology
  • Adaptive Immunity
  • T Cells
  • CD

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

Applications

Target

• FunctionIdentifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
• Involvement in diseaseDefects in CD8A are a cause of familial CD8 deficiency (CD8 deficiency) [MIM:608957]. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections.
• Sequence similaritiesContains 1 Ig-like V-type (immunoglobulin-like) domain.
• Post-translational
  modificationsAll of the five most C-terminal cysteines form inter-chain disulfide bonds in dimers and higher multimers, while the four N-terminal cysteines do not.
• Cellular localizationSecreted and Cell membrane.

Target information above from: UniProt accession P01732 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 925 Human
  • Omim: 186910 Human
  • SwissProt: P01732 Human
  • Unigene: 85258 Human

• Alternative names
  CD 8 antibodyCD 8A antibodyCD 8B antibody

  CD8 antibodyCD8 antigen alpha polypeptide antibodyCD8 antigen, alpha polypeptide (p32) antibodyCD8A antibodyCD8a antigen antibodyCD8a molecule antibodyCD8A_HUMAN antibodyCD8B antibodyCD8b antigen antibodyCD8b antigen isoform 2 antibodyCD8b molecule antibodyCD8B protein antibodyCD8B1 antibodyLeu2 antibodyLeu2 T lymphocyte antigen antibodyLy3 antibodyLYT3 antibodyMAL antibodyMGC119115 antibodyOKT8 T Cell antigen antibodyp32 antibodyT cell antigen Leu2 antibodyT cell co receptor antibodyT cell surface glycoprotein CD8 alpha chain antibodyT cell surface glycoprotein CD8 beta chain antibodyT lymphocyte differentiation antigen T8/Leu 2 antibodyT-cell surface glycoprotein CD8 alpha chain antibodyT-lymphocyte differentiation antigen T8/Leu-2 antibodyT8 T cell antigen antibody

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Anti-CD8 antibody [YTC 182.20] (FITC) images

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  Flow Cytometry / FACS - CD8 antibody [YTC 182.20] (FITC) (ab34153)
  Staining of human peripheral blood lymphocytes with rat anti human ab34153