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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab62636 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-Fr
Flow Cyt
  • Application notesFlow Cyt: 1/10 - 1/50. Use 10µl to label 1x106 cells in 100µl.
    IHC-Fr: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionInvolved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.
    • Tissue specificityExpressed on activated B-cells, macrophages and dendritic cells.
    • Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Cellular localizationMembrane.

      • Target information above from: UniProt accession P33681 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          Activation B7 1 antigen antibodyActivation B7-1 antigen antibodyActivation B71 antigen antibody
          B lymphocyte activation antigen B7 antibodyB7 antibodyBB1 antibodyCD 80 antibodyCD28 antigen ligand 1 B7 1 antigen antibodyCD28 antigen ligand 1 B71 antigen antibodyCD28LG antibodyCD28LG1 antibodyCD80 antibodyCD80 antibodyCD80 antigen antibodyCD80 antigen precursor antibodyCD80 molecule antibodyCD80_HUMAN antibodyCostimulatory factor CD80 antibodyCTLA 4 counter receptor B7.1 antibodyCTLA-4 counter-receptor B7.1 antibodyLAB 7 antibodyLAB7 antibodyT lymphocyte activation antigen CD80 antibodyT-lymphocyte activation antigen CD80 antibody
        see all

      References for Anti-CD80 antibody [RM80] (ab62636)

      This product has been referenced in:
      • Ogawa S  et al. Opposing effects of anti-activation-inducible lymphocyte-immunomodulatory molecule/inducible costimulator antibody on the development of acute versus chronic graft-versus-host disease. J Immunol 167:5741-8 (2001). Read more (PubMed: 11698447) »

      See 1 Publication for this product

      Publishing research using ab62636 ? Please let us know so that we can cite the reference in this datasheet

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      I need a blocking antibody to CD80 that will work in mouse but will not react to rat.

      Thank you for contacting us. I have had an opportunity to review our catalog and have found four products that may fulfill your needs. Each will react with mouse. Three have been produced in rat (ab62636, ab25208, ab40981)so cross reactivity will not be a...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"