Anti-CD86 antibody [2D10] (Phycoerythrin) (ab25594)

Overview

• Product nameAnti-CD86 antibody [2D10] (Phycoerythrin)See all CD86 primary antibodies ...
• Description
  Rat monoclonal [2D10] to CD86 (Phycoerythrin)
• ConjugationPhycoerythrin
• SpecificityCD86, B72 costimulatory molecule and a ligand for CD28 and CD152
• Tested applicationsIP, Flow Cyt, IHC-Fr, Blocking more details
• Species reactivity
  Reacts with: Mouse
  
• Immunogen

  The details of the immunogen for this antibody are not available.

Properties

• FormLiquid
• Storage instructionsStore at +4°C in the dark. Do not freeze.
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: 16% Sucrose, PBS and stabilizing agent.
• Concentration information loading...
• PurityIgG fraction
• Primary antibody notes Since CD86/B72 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response.
• Clonality Monoclonal
• Clone number2D10
• IsotypeIgG2b
• Light chain typekappa
• Research Areas
  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Monocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Lymphoid
  • B Lymphocytic Lineage

  • Stem Cells
  • Hematopoietic Progenitors
  • Myeloid
  • Dendritic Cell Lineage

  • Microbiology
  • Interspecies Interaction
  • Host Virus Interaction

  • Immunology
  • Adaptive Immunity
  • T Cells
  • CD

  • Immunology
  • Adaptive Immunity
  • Regulatory T Cells

  • Immunology
  • Cell Type Markers
  • CD
  • Non-lineage

Applications

Target

• FunctionReceptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
• Tissue specificityExpressed by activated B-lymphocytes and monocytes.
• Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
  Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• Post-translational
  modificationsPolyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
• Cellular localizationMembrane.

Target information above from: UniProt accession P42081 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 12524 Mouse
  • SwissProt: P42082 Mouse
  • Unigene: 1452 Mouse

• Alternative names
  Activation B7 2 antigen antibodyActivation B7-2 antigen 3 antibodyActivation B7-2 antigen antibody

  Activation B72 antigen antibodyB lymphocyte activation antigen B7 2 antibodyB lymphocyte activation antigen B72 antibodyB-lymphocyte activation antigen B7-2 2 antibodyB-lymphocyte activation antigen B7-2 antibodyB7 2 antibodyB7 2 antigen antibodyB7 antibodyB7-2 antibodyB7.2 antibodyB70 antibodyB72 antigen antibodyBU63 antibodyCD 86 antibodyCD28 antigen ligand 2 2 antibodyCD28 antigen ligand 2 antibodyCd28l2 antibodyCD28LG2 antibodyCD28LG2 antibodyCD86 antibodyCD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2 antibodyCD86 antigen (CD28 antigen ligand 2, B7-2 antigen) antibodyCD86 antigen antibodyCD86 molecule antibodyCD86_HUMAN antibodyCLS1 antibodyCTLA 4 counter receptor B7 2 antibodyCTLA 4 counter receptor B7.2 antibodyCTLA-4 counter-receptor B7.2 2, 3 antibodyCTLA-4 counter-receptor B7.2 antibodyCTLA4 counter receptor B72 antibodyEarly T-cell costimulatory molecule 1 antibodyETC-1 antibodyFUN 1 antibodyFUN-1 antibodyFUN1 antibodyLAB72 antibodyLAB72 antibodyLy-58 antibodyLy58 antibodyMB7 antibodyMB7-2 antibodyMembrane glycoprotein antibodyMGC34413 antibodyT lymphocyte activation antigen CD86 antibodyT-lymphocyte activation antigen CD86 antibodyTS/A-2 antibody

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