Overview

  • Product nameAnti-CD86 antibody [B-T7] (FITC)See all CD86 primary antibodies ...
  • Description
    Mouse monoclonal [B-T7] to CD86 (FITC)
  • ConjugationFITC. Ex: 493nm, Em: 528nm
  • Specificityab27361 recognises B7.2, B70 antigen, an 80 kDa protein.
  • Tested applicationsFlow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human B70 transfected P815 cell line

  • Positive control
    • Monocyte cells and whole blood.
  • General notesHybridoma: Myeloma X63/AG.8653 x Balb/c spleen cells. Workshop: VI

Properties

Applications

Our Abpromise guarantee covers the use of ab27361 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notesFlow Cyt: Use 10µl for 106 cells or 100µl whole blood.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
    • Tissue specificityExpressed by activated B-lymphocytes and monocytes.
    • Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
    • Post-translational
      modifications
      Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Activation B7 2 antigen antibody
      • Activation B7-2 antigen 3 antibody
      • Activation B7-2 antigen antibody
      • Activation B72 antigen antibody
      • B lymphocyte activation antigen B7 2 antibody
      • B lymphocyte activation antigen B72 antibody
      • B-lymphocyte activation antigen B7-2 2 antibody
      • B-lymphocyte activation antigen B7-2 antibody
      • B7 2 antibody
      • B7 2 antigen antibody
      • B7 antibody
      • B7-2 antibody
      • B7.2 antibody
      • B70 antibody
      • B72 antigen antibody
      • BU63 antibody
      • CD 86 antibody
      • CD28 antigen ligand 2 2 antibody
      • CD28 antigen ligand 2 antibody
      • Cd28l2 antibody
      • CD28LG2 antibody
      • CD28LG2 antibody
      • CD86 antibody
      • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 1, 2 antibody
      • CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) antibody
      • CD86 antigen antibody
      • CD86 molecule antibody
      • CD86_HUMAN antibody
      • CLS1 antibody
      • CTLA 4 counter receptor B7 2 antibody
      • CTLA 4 counter receptor B7.2 antibody
      • CTLA-4 counter-receptor B7.2 2, 3 antibody
      • CTLA-4 counter-receptor B7.2 antibody
      • CTLA4 counter receptor B72 antibody
      • Early T-cell costimulatory molecule 1 antibody
      • ETC-1 antibody
      • FUN 1 antibody
      • FUN-1 antibody
      • FUN1 antibody
      • LAB72 antibody
      • LAB72 antibody
      • Ly-58 antibody
      • Ly58 antibody
      • MB7 antibody
      • MB7-2 antibody
      • Membrane glycoprotein antibody
      • MGC34413 antibody
      • T lymphocyte activation antigen CD86 antibody
      • T-lymphocyte activation antigen CD86 antibody
      • TS/A-2 antibody
      see all

    Anti-CD86 antibody [B-T7] (FITC) images

    • A typical staining pattern using ab27361 of Monocytes.

    References for Anti-CD86 antibody [B-T7] (FITC) (ab27361)

    This product has been referenced in:
    • Puig-Kröger A  et al. Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells. Blood 98:2175-82 (2001). Read more (PubMed: 11568005) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"