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Anti-CD89 antibody [MIP8a] (ab22520)

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Overview

Product name

Anti-CD89 antibody [MIP8a]
See all CD89 products (6) ...

Description

Mouse monoclonal [MIP8a] to CD89

Specificity

This antibody recognises the human CD89 cell surface antigen, blocks the binding of IgA to this target and also inhibits neutrophil phagocytosis of IgA complexes.

Tested applications

Flow Cyt, IP, WB, ELISAmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length protein (Human). Recombinant soluble human Fc alpha R

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.09% Sodium Azide
Constituents: PBS, pH 7.4

Concentration

Concentration information loading...

Purity

IgG fraction

Clonality

Monoclonal

Clone number

MIP8a

Isotype

IgG1

Research areas

Immunology >> Cell Type Markers >> CD >> Non-lineage

Applications

Show applications key

Our Abpromise guarantee covers the use of ab22520 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.

Tissue specificity

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Cellular localization

Secreted and Cell membrane.

Target information above from: UniProt accessionP24071 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • CD89 antibody
  • Fc alpha receptor antibody
  • FCAR antibody
  • FCAR_HUMAN antibody
  • IgA Fc receptor antibody
  • Immunoglobulin alpha Fc receptor antibody
see all

Database links

References for Anti-CD89 antibody [MIP8a] (ab22520)

This product has been referenced in:

  • Zhang Wet al. Neutrophil lactoferrin release induced by IgA immune complexes differed from that induced by cross-linking of fcalpha receptors (FcalphaR) with a monoclonal antibody, MIP8a. Clin Exp Immunol 121:106-11 (2000).Read more (PubMed: 10886246) »

See 1 publication for this product

Publishing research using ab22520? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"