Anti-CD95 antibody [B-D29] - Azide free (ab34359)

Overview

• Product nameAnti-CD95 antibody [B-D29] - Azide freeSee all CD95 primary antibodies ...
• Description
  Mouse monoclonal [B-D29] to CD95 - Azide free
• Tested applicationsFunctional Studies more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Recombinant full length protein (Human) - purified CD95 antigen.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None.
  Constituents: PBS
• Concentration information loading...
• Purification notesab34359 was purified by ion exchange chromatography. This product was sterile filtered through 0.22 µm and treated to remove endotoxins.
• Clonality Monoclonal
• Clone numberB-D29
• Myelomax63-Ag8.653
• IsotypeIgG1
• Research Areas
  • Immunology
  • Cell Type Markers
  • CD
  • Cytokines

  • Immunology
  • Innate Immunity
  • Cytokines
  • TNF Superfamily

  • Cell Biology
  • Apoptosis
  • Receptors
  • Death Receptors

Applications

Target

• FunctionReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
• Tissue specificityIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
• Involvement in diseaseDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
• Sequence similaritiesContains 1 death domain.
  Contains 3 TNFR-Cys repeats.
• DomainContains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
• Cellular localizationSecreted and Cell membrane.

Target information above from: UniProt accession P25445 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 355 Human
  • Omim: 134637 Human
  • SwissProt: P25445 Human
  • Unigene: 244139 Human

• Alternative names
  ALPS 1A antibodyALPS1A antibodyAPO 1 antibody

  Apo 1 antigen antibodyAPO 1 cell surface antigen antibodyApo-1 antigen antibodyAPO1 antibodyApo1 antigen antibodyAPO1 cell surface antigen antibodyApoptosis antigen 1 antibodyApoptosis APO1 antigen 1 antibodyApoptosis mediating surface antigen FAS antibodyApoptosis-mediating surface antigen FAS antibodyAPT 1 antibodyAPT1 antibodyAPT1 antibodyCD 95 antibodyCD 95 antigen antibodyCD95 antibodyCD95 antigen antibodyDelta Fas antibodyDelta Fas/APO 1/CD95 antibodyDelta Fas/APO1/CD95 antibodyFas (TNF receptor superfamily member 6) antibodyFAS 1 antibodyFAS 827dupA antibodyFas AMA antibodyFAS antibodyFAS Antigen antibodyFAS Antigen antibodyFAS1 antibodyFASL receptor antibodyFASLG receptor antibodyFASTM antibodyTNF receptor superfamily member 6 antibodyTNF receptor superfamily, member 6 antibodyTNFR6 antibodyTNFRSF 6 antibodyTNFRSF6 antibodyTNFRSF6 antibodyTNR6_HUMAN antibodyTumor necrosis factor receptor superfamily member 6 antibody

  see all