Anti-CD95 antibody [DX2] - BSA and Azide free (ab25633)
- Product nameAnti-CD95 antibody [DX2] - BSA and Azide freeSee all CD95 primary antibodies ...
- DescriptionMouse monoclonal [DX2] to CD95 - BSA and Azide free
- Specificityab25633 recognises human CD95
- Tested applicationsFlow Cyt, IHC-Fr, IP more details
- Species reactivityReacts with: Human
The details of the immunogen for this antibody are not available. (Human)
- Positive controlJurkat human lymphoma cell line
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: None
Constituents: Sodium chloride, Borate buffered saline, pH 8.2
- Concentration information loading...
- PurityIgG fraction
- Clonality Monoclonal
- Clone numberDX2
- Research Areas
Our Abpromise guarantee covers the use of ab25633 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Flow Cyt||Flow Cyt: Use 1µg for 106 cells.|
|IHC-Fr||IHC-Fr: Use at an assay dependent dilution.|
|IP||IP: Use at an assay dependent dilution.|
- FunctionReceptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
- Tissue specificityIsoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.
- Involvement in diseaseDefects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
- Sequence similaritiesContains 1 death domain.
Contains 3 TNFR-Cys repeats.
- DomainContains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.
- Cellular localizationSecreted and Cell membrane.
- ALPS 1A antibodyALPS1A antibodyAPO 1 antibody
- Apo 1 antigen antibodyAPO 1 cell surface antigen antibodyApo-1 antigen antibodyAPO1 antibodyApo1 antigen antibodyAPO1 cell surface antigen antibodyApoptosis antigen 1 antibodyApoptosis APO1 antigen 1 antibodyApoptosis mediating surface antigen FAS antibodyApoptosis-mediating surface antigen FAS antibodyAPT 1 antibodyAPT1 antibodyAPT1 antibodyCD 95 antibodyCD 95 antigen antibodyCD95 antibodyCD95 antigen antibodyDelta Fas antibodyDelta Fas/APO 1/CD95 antibodyDelta Fas/APO1/CD95 antibodyFas (TNF receptor superfamily member 6) antibodyFAS 1 antibodyFAS 827dupA antibodyFas AMA antibodyFAS antibodyFAS Antigen antibodyFAS Antigen antibodyFAS1 antibodyFASL receptor antibodyFASLG receptor antibodyFASTM antibodyTNF receptor superfamily member 6 antibodyTNF receptor superfamily, member 6 antibodyTNFR6 antibodyTNFRSF 6 antibodyTNFRSF6 antibodyTNFRSF6 antibodyTNR6_HUMAN antibodyTumor necrosis factor receptor superfamily member 6 antibody
References for Anti-CD95 antibody [DX2] - BSA and Azide free (ab25633)
This product has been referenced in:
- Hunt ME & Brown DR Mycoplasma alligatoris infection promotes CD95 (FasR) expression and apoptosis of primary cardiac fibroblasts. Clin Diagn Lab Immunol 12:1370-7 (2005). Read more (PubMed: 16339059) »